Calciun channel Blockers


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how do calcium channel blockers (CCBs) effect the electrophysiology of cardiac contractile cells on fig. attached

see fig. attached

Jun 16th, 2015

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The calcium-channel blockers represent a group of organic chemical structures that share the ability to inhibit Ca2+ entry into excitable cells. In cardiac contractile cells, inhibition of Ca2+ entry blunts the ability of Ca2+ to serve as an intracellular messenger. Thus, calcium-channel blockers have a negative inotropic effect on the working myocardial cells of the atria and ventricles. Calcium-channel blockers also have effects on impulse formation and conduction in some regions of the heart.

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Jun 16th, 2015

But how is CCBs translate/ effects contractile force by the heart via the fig. attached?

Jun 16th, 2015

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