My PICO question is, in patients with kidney injury who trigger for sepsis due to, fever, and slightly elevated
white count and elevated heart rate, is it appropriate to initiate fluid boluses immediately or would it be
beneficial to first see what the lactic acid level comes back as and only if elevated then initiate fluid boluses?
Review the article, “Formulating the Evidence Based Practice Question: A Review of the
Frameworks,” found in the Learning Resources for this week. Focus on the PICOT model for
guiding the development of research questions.
Review the section beginning on page 71 of the course text, titled, “Developing and Refining
Research Problems” in the course text, which focuses on analyzing the feasibility of a research
Reflect on an issue or problem that you have noticed in your nursing practice. Consider the
significance of this issue or problem.
Generate at least five questions that relate to the issue which you have identified. Use the
criteria in your course text to select one question that would be most appropriate in terms of
significance, feasibility, and interest. Be prepared to explain your rationale.
Formulate a preliminary PICO question—one that is answerable—based on your analysis. What
are the PICO variables (patient/population, intervention/issue, comparison, and outcome) for
Note: Not all of these variables may be appropriate to every question. Be sure to analyze which are and
are not relevant to your specific question.
Using the PICOT variables that you determined for your question, develop a list of at least 10
keywords that could be used when conducting a literature search to investigate current
research pertaining to the question.
Write a 3- to 4-page paper that includes the following:
A summary of your area of interest, an identification of the problem that you have selected, and
an explanation of the significance of this problem for nursing practice
The 5 questions you have generated and a description of how you analyzed them for feasibility
Your preliminary PICOT question and a description of each PICOT variable relevant to your
At least 10 possible keywords that could be used when conducting a literature search for your
PICOT question and a rationale for your selections
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