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LTAs is a surface-associated adhesion amphiphile from Gram-positive bacteria and legislator to autolytic wall enzymes.
It can trigger the release from neutrophilis and macrophages of reactive oxygen and nitrogen species, bacterial cationic peptides, growth factors and cytotoxic cytokines, which may act in synergy to amplify cell damage.
It can react with circulating antibodies and activate the compliment cascade to induce a passive immune kill phenomenon.
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Sep 26th, 2015
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