Paraphrasing to rewrite a short essay?

Anonymous
timer Asked: May 18th, 2019
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I need paraphrasing to rewrite a short essay. Its just 2-3 pages . I need them within 24hrs.

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The effect of the early administration of tranexamic acid (TXA) Among trauma patients who survive to reach hospital, exsanguination is a common cause of death. A widely practicable treatment that reduces blood loss after trauma could prevent thousands of premature deaths each year. The CRASH-2 trial aimed to determine the effect of the early administration of tranexamic acid on death and transfusion requirement in bleeding trauma patients. In addition, the effort of tranexamic acid on the risk of vascular occlusive events was assessed. METHODS: This randomised controlled trial was undertaken in 274 hospitals in 40 countries. 20 211 adult trauma patients with, or at risk of significant bleeding were randomly assigned within 8 h of injury to either tranexamic acid (loading dose 1 g over 10 min then infusion of 1 g over 8 h) or matching placebo. Randomisation was balanced by centre, with an allocation sequence based on a block size of eight, generated with a computer random number generator Both participants and study staff (site investigators and trial coordinating centre staff) were masked to treatment allocation. The primary outcome was death in hospital within 4 weeks of injury, and was described with the following categories: bleeding, vascular occlusion (myocardial infarction, stroke and pulmonary embolism), multiorgan failure, head injury, and other AL analyses were by intention to treat. RESULTS: 10096 patients were allocated to tranexamic acid and 10 115 to placebo, of whom 10060 and 10067, respectively, were analysed. All-cause mortality was significantly reduced with tranexamic acid (1463 [14.5%] tranexamic acid group vs 1613 [160%] placebo group; relative risk 0.91, 95% CI 085-097; p = 00035). The risk of death due to bleeding was significantly reduced (489 [49%] vs 574 [5-7%]; relative risk 0-85, 95% CI 0.76-0.96; p = 0-0077). CONCLUSION: Tranexamic acid safely reduced the risk of death in bleeding trauma patients in this study On the basis of these results, tranexamic acid should be considered for use in bleeding trauma patients. Future work [the Clinical Randomisation of an Antifibrinolytic in Significant Head injury-3 (CRASH-3) trial] will evaluate the effectiveness and safety of TXA in the treatments of isolated traumatic brain injury (http://crash3.lshtm.ac.uk/). The PATCH-Trauma Study is an international multi-centre, randomised, double-blind, placebocontrolled trial of pre-hospital treatment with tranexamic acid for severely injured patients at risk of acute traumatic coagulopathy. The study aims to determine the effects of early administration of tranexamic acid on survival and recovery of severely injured patients treated within advanced trauma systems. https://www.patchtrauma.org/ Overview: • International multi-centre, double-blind, randomised, placebo-controlled trial • 1200 participants at high risk of acute traumatic coagulopathy • Pre-hospital treatment with tranexamic acid in advanced trauma systems • Mortality and functional recovery at six months • Assessment of fibrinolysis, coagulation, and thrombotic events ...
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Tutor_StefanD
School: University of Maryland

Attached is the complete work. Feel free to ask for any corrections or clarifications

Implications of the early administering of tranexamic acid
Exsanguination is a leading cause of death in patients experiencing trauma who are lucky
enough to reach the hospital. A lot of premature deaths that occur annually may be avoided using
a treatment that is widely practicable. This treatment focuses on reducing blood loss in trauma
patients. The CRASH-2 trial aims at determining the implication of early administering of
tranexamic acid in the event of a death and transfusion requirement in trauma victims experiencing
bleeding. Additionally, assessment of the work of tranexamic acid in regard to the risks of vascular
occl...

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Anonymous
Excellent job

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