explore one of the topics below, comparing and contrasting Sundiata and Popul Vuh, and write a 6-10 paragraph essay arguing for and supporting your conclusions to submit as a well-developed essay.  This assignment will build your writing and analysis skills. You may be able to further flesh out the writing you have already done in discussions towards these goals.  If you choose a different topic than the ones you have already written, the discussion posts and responses may still be useful and inspiring.  However, be careful you don't plagiarize your classmates' work.  We encourage you to use the background material in the course to flush out your own original interpretations and arguments; researching other secondary sources is not required for this assignment, of other sources will not be tolerated.  Tasks: First, choose one of the following two topics: Topic #1:  One of the Five Great Themes of World Literature is “Sacred & Secular.” As stated in Unit 1B of this course, “We will find in our study of literary masterpieces from the past many intricate negotiations between the divine and the earthly realms.” Discuss what we learn about how divine powers and earthly beings interact in Sundiata (in an area with a syncretic religion) and Popol Vuh (which is not a sacred text but presents the Mayan cosmology).  Which values embodied by these interactions are considered significant by their societies? One of the passages you should quote (all or in part) and analyze is the following: At the time when Sundiata was preparing to assert his claim over the kingdom of his fathers, Soumaoro was the king of kings, the most powerful king in all the lands of the setting sun. The fortified town of Sosso was the bulwark of fetishism against the word of Allah. For a long time, Soumaoro defied the whole world. Since his accession to the throne of Sosso he had defeated nine kings whose heads served him as fetishes in his macabre chamber. . . .  So his countless sofas were very brave since they believed their king to be invincible. But Soumaoro was an evil demon and his reign had produced nothing but bloodshed. Nothing was taboo for him. His greatest pleasure was publicly to flog venerable old men (41). Topic #2:  Both Sundiata and Popol Vuh deal centrally with a heroic quest.  Unit 1B's introduction to the Five Great Themes of World Literature states concerning the hero:  "The surest way to understand what a culture of the past most values is to focus on what it considers heroic, in that a culture recognizes its heroes as embodying its most important ideas, the values that are essential."  Discuss what forces Sundiata and the Hero Twins Hunahpu and Xbalanque have to overcome and how they go about doing it. For Sundiata your presentation will probably focus on Sundiata’s historical destiny; in Popol Vuh, the Twins’ quest will have a more mythic quality, but you probably will focus on the meaning for the Mayan culture of the mythic events.  One of the passages you should quote (all or in part) and analyze is the following: Hunahpú was sacrificed by Xbalanqué; one by one his arms and his legs were sliced off, his head was cut from his body and carried away; his heart was torn from his breast and thrown onto the grass. All the Lords of Xibalba were fascinated. They looked on in wonder, but really it was only the dance of one man; it was Xbalanqué. "Get up!" he said, and instantly [Hunahpú] returned to life . . .  "Do the same with us! Sacrifice us!" they said. "Cut us into pieces, one by one!" Hun-Camé and Vucub-Camé said to Hunahpú and Xbalanqué.  . . . And so it happened that they first sacrificed the one, who was the chief and [Lord of Xibalba], the one called Hun-Camé, king of Xibalba. And when Hun-Camé was dead, they overpowered Vucub-Camé, and they did not bring either of them back to life (Part II, Ch. 13). Second, write an essay presenting your argument.  Include quotations from the texts as well as additional details that illustrate and enhance the points you are making.  Use the following as an outline of what to include: Explain the general topic and relevant themes (e.g. sacred and secular, heroes' journeys) and any relevant terms for that topic (suggested 1-2 paragraphs). State your thesis - a general statement about your conclusions. Apply that topic to both Sundiata and Popul Vuh  

Police received a tip that a man has been selling drugs out of his house and that there are several teenagers who work for him as peddlers. Two officers stopped him outside his house and asked if he would accompany them to the station to answer some questions. He agreed to come along. On the way to the station, the officers pointed to children walking around and mentioned that penalty is heavy for those who sell drugs to children, or involve them in selling drugs. The suspect said, “Hey, I may have dealt some drugs, but I have never sold to kids or dealt with kids.“ When they arrived at the station, the officers arrested him and read him his rights, based on the tip they had received initially, and his admission to selling drugs. Then he was taken to a room and confronted with being the center of a drug ring that uses teenagers to distribute drugs. He asked, “Maybe I should call my lawyer?“ The officers replied, “Telling us the truth will do much more for you than seeing a lawyer.“ The man admitted to his involvement and called his lawyer afterward. answers the following questions: Assume that you are the judge on this case. What motions to dismiss would you expect to hear from the defense in the case? How would the prosecution counter these motions? What are the key issues arising from the defendant's admission made while in the police car? Is the case within the ambit of Miranda, or outside it? Why do you think so? Should the defendant's admission in the police car be admissible? Why or why not? Discuss with reference to United States v. Patane (2004). What are the key issues surrounding the defendant's admission while at the police station? Explain in detail with reference to the Miranda warnings and the fact that during interrogation the defendant had mentioned, not demanded, a lawyer. Should the admission made at the station be admissible? Why or why not? What would have been the effect on this case if the suspect had not asked for his lawyer? Discuss with reference to Escobedo v. Illinois. What evidence could be added to the scenario to strengthen a defense attorney's motion to dismiss the evidence? What evidence could be added to weaken it?

Work from the Brown and Goldstein lab provided insights into cholesterol homeostasis that were used to develop several of the LDL cholesterol-lowering therapies, including statins that remain in use today. However, in some patients, statins were not as effective as expected, suggestive of additional mechanisms regulating the LDL receptor. Investigate other LDL cholesterol-lowering therapies (other than PCSK-9 inhibitors), select 1, and compare and contrast the mechanisms of action between the class of drug you select and statins. Include side effects for both types of drugs and information on their efficacy.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC42711...https://link.springer.com/article/10.1007%2Fs00395...