Writing
University of California Surgery for Blocked Arteries Case Study Paper

University of California Davis

Question Description

Can you help me understand this Philosophy question?

Do a full six-step evaluation of the causal study located at the link below, including a diagram of the design of the study and a diagram of the data: (the attach PDF)

Part of the data (in italics and noted within the PDF of the media report of the study) had to be added from unpublished information from the clinical trial itself because the otherwise very detailed report by the journalist writing about it in the New York Times left it out. The study is unpublished because the results were just announced on November 16th. Publication is expected in 2020. So, this is real news!

After you write your six-step evaluation, add a 7th "step" to your report to offer a brief reflection (no more than a paragraph) indicating what you could not have done in your evaluation had the italicized information I added to the newspaper report not been included.

Your report will be graded out of 16 points: 2 points each for steps 1-6 of the six-step evaluation. Your 7th "step" reflection is worth 2 points. And there are 2 points (1 each) for grammar/composition and argument coherence. There is no need for a bibliography since we know what study you are discussing.

Your report should be 3-5 pages long (double spaced), including diagrams. So, that means 2-3 pages for your six-step evaluation plus a page with the two diagrams. Some people write a bit more per step than others, so that's why there is a range of lengths from 3-5 pages.


Unformatted Attachment Preview

Surgery for Blocked Arteries Is Often Unwarranted, Researchers Find By Gina Kolata Nov. 16, 2019, The New York Times The findings of a large federal study on bypass surgeries and stents call into question the medical care provided to tens of thousands of heart disease patients with blocked coronary arteries, scientists reported at the annual meeting of the American Heart Association on Saturday. The new study found that patients who received drug therapy alone did not experience more heart attacks or die more often than those who also received bypass surgery or stents, tiny wire cages used to open narrowed arteries. That finding held true for patients with several severely blocked coronary arteries. Stenting and bypass procedures, however, did help some patients with intractable chest pain, called angina. “You would think that if you fix the blockage the patient will feel better or do better,” said Dr. Alice Jacobs, director of Cath Lab and Interventional Cardiology at Boston University. The study, she added, “certainly will challenge our clinical thinking.” This is far from the first study to suggest that stents and bypass are overused. But previous results have not deterred doctors, who have called earlier research on the subject inconclusive and the design of the trials flawed. Previous studies did not adequately control for risk factors, like LDL cholesterol, that might have affected outcomes, said Dr. Elliott Antman, a senior physician at Brigham and Women’s Hospital in Boston. Nor did those trials include today’s improved stents, which secrete drugs intended to prevent opened arteries from closing again. With its size and rigorous design, the new study, called Ischemia, was intended to settle questions about the benefits of stents and bypass. “This is an extraordinarily important trial,” said Dr. Glenn Levine, director of cardiac care at Baylor College of Medicine in Houston. The results will be incorporated into treatment guidelines, added Dr. Levine, who sits on the guidelines committee of the American Heart Association. The participants in Ischemia were not experiencing a heart attack, like Senator Bernie Sanders, nor did they have blockages of the left main coronary artery, two situations in which opening arteries with stents can be lifesaving. Instead, the patients had narrowed arteries that were discovered with exercise stress tests. With 5,179 participants followed for a median of three and a half years, Ischemia is the largest trial to address the effect of opening blocked arteries in nonemergency situations and the first to include today’s powerful drug regimens, which doctors refer to as medical therapy. All the patients had moderate to severe blockages in coronary arteries. Most had some history of chest pain, although one in three had no chest pain in the month before enrollment in the study. One in five experienced chest pain at least once a week. All participants were regularly counseled to adhere to medical therapy. Depending on the patient’s condition, the therapy variously included high doses of statins and other cholesterollowering drugs, blood pressure medications, aspirin and, for those with heart damage, a drug to slow the heart rate. Those who got stents also took powerful anti-clotting drugs for six months to a year. Patients were randomly assigned to have medical therapy alone or an intervention and medical therapy. Of those in the intervention group, three-quarters received stents; the others received bypass surgery. The number of deaths among those who had the invasive procedure (stents or bypass), n=388, was 145, compared to 144 among the patients who received medication alone (the conservative procedure), n=389. The number of patients who had heart attacks was 276 in the stent and bypass group, compared with 314 in the medication group, an insignificant difference. [Italicized information added from the unpublished clinical trials report.] An angiogram of the arteries of a patient who was part of the trial, prior to receiving a stent. NYU Langone Health The same patient, after receiving a stent. NYU Langone Health Dr. Judith Hochman, senior associate dean of clinical sciences at N.Y.U. Langone Health and chair of the study, had expected that those with the most severe chest pain and blockages would benefit from stents or bypass. But “there was no suggestion that any subgroup benefited,” she said. Ischemia’s results are consistent with current understanding of heart disease. Researchers have learned that a patient with a narrowed artery may have plaques not just in a single blocked area, but throughout the coronary arteries. There is no way to predict which of those plaques will break open and cause a heart attack. Stents and bypass treat only areas that are obviously narrowed, but medical therapy treats the entire arterial system. Yet when a cardiologist sees a blockage, the temptation for doctor and patient alike is to get rid of it quickly, said Dr. David Maron, director of preventive cardiology at Stanford University, the study’s other co-chair. When an exercise stress test indicates a narrowing, most doctors send patients to a cardiac catheterization lab to look for blockages, Dr. Maron said. If there is a blockage, the usual practice is to open it with a stent. If stenting is not feasible — because of the configuration of the patient’s arteries, for example — bypass surgery is usually the next step. Patients with abnormal stress tests should talk to their doctors about the options, Dr. Maron said. If a patient has chest pain despite taking recommended medications, a stent or bypass might help improve quality of life. Still, he said, patients have time to make considered decisions. “You don’t have to rush to the cath lab because, OMG, you will have a heart attack soon or drop dead,” Dr. Maron said. “If you have had no angina in the last month, there is no benefit to an invasive strategy.” Stenting costs an average of $25,000 per patient; bypass surgery costs an average of $45,000 in the United States. The nation could save more than $775 million a year by not giving stents to the 31,000 patients who get the devices even though they have no chest pain, Dr. Hochman said. But the conventional wisdom among cardiologists is that the sort of medical therapy that patients got in Ischemia is just not feasible in the real world, said Dr. William E. Boden, scientific director of the clinical trials network at VA Boston Healthcare System, who was a member of the study’s leadership committee. Doctors often say that making sure patients adhere to the therapy is “too demanding, and we don’t have time for it,” he said. But getting a stent does not obviate the need for medical therapy, Dr. Boden noted. Since patients with stents need an additional anti-clotting drug, they actually wind up taking more medication than patients who are treated with drugs alone. About a third of stent patients develop chest pain again within 30 days to six months and end up with receiving another stent, Dr. Boden added. “We have to finally get past the whining about how hard optimal medical therapy is and begin in earnest to educate our patients as to what works and is effective and what isn’t,” Dr. Boden said. ...
Purchase answer to see full attachment
Student has agreed that all tutoring, explanations, and answers provided by the tutor will be used to help in the learning process and in accordance with Studypool's honor code & terms of service.

Final Answer

Attached.

Running Head: HEART ATTACKS

1

HEART ATTACKS
By (Name)
Course
Professor
Institutional affiliation
Date

HEART ATTACKS

2

Introduction
Heart attacks occur as a result of the death of a segment of cardiac muscle due to
insufficient blood supply. A blockage or blockages cause the low supply of blood in the coronary
artery. The death of cardiac muscles causes electrical instability of its tissue and leads to chest
discomforts and pain. Individuals over the age of 45 have an increased risk of getting heart attacks.
Obesity, smoking, and other lifestyle factors also increase the risk of getting heart diseases. Heart
attacks are accompanied by symptoms of pain, tightness, pressure, and aching of the arms or chest.
The pain symptoms spread to the back, neck, or jaw of the individual requiring immediate medical
attention. Other symptoms include coughing, vomiting, nausea, dizziness, chest pain, dyspnea, and
restlessness. The short-term complications of heart attacks include arrhythmias, hypoxemia,
pulmonary edema, cardiogenic shock, thrombosis, and ventricular aneurysm. The long-term
complications include angina, congestive heart, failure, aneurysm, edema, erectile dysfunction,
low libido, and pericarditis. The treatment for heart attacks includes the use of medication and the
use of invasive treatment methods such as bypass surgery and stenting. This paper evaluates
surgery for blocked arteries is an often unwarranted article by Gina Kolata.
Definition of the problem
The federal research on stents and bypass surgeries raises a lot of questions on the
healthcare provided to millions of Americans. The American Heart Association shows that patients
who only receive medication rather than bypass surgeries or stents e...

TutorLarra (21847)
University of Virginia

Anonymous
Solid work, thanks.

Anonymous
The tutor was great. I’m satisfied with the service.

Anonymous
Goes above and beyond expectations !

Studypool
4.7
Trustpilot
4.5
Sitejabber
4.4