Immunology Quiz-1 Each answer is equal 0.1 points (5 points – maximum) Name_______________________________________________________________________ True or false? 1) The adaptive immune response is non-specific 2) The adaptive defense must first be primed by exposure to an antigen 3) Humoral immunity is mediated by cells 4) Immunological memory - protection against the recurring infection 5) In vivo stem cells are rapidly dividing 6) Neutrophils are granulocytes 7) Both basophils and mast cells are responsible for inflammatory and allergic reactions 8) Monocytes migrate from the blood stream into tissues and become dendritic cells 9) Dendritic cells process and present foreign molecules as antigens to T-lymphocytes 10) Plasma cells secrete large volumes of antibodies 11) Lymphocytes belong to granulocytes 12) IgM are widely used in molecular and cell biology as well as in clinical lab applications 13) Signal transduction means that the original signaling molecule is not physically passed along a signaling pathway 14) Autocrine signals target cells in the vicinity of the emitting cell 15) Antigens are signaling molecules for immune cells 16) Complement enhances inflammation 17) Complement is the main factor in the membrane attack complex 18) The resulting from complement activation smaller polypeptide fragments induce and promote inflammation 19) Properdin enhances complement activation 20) Lysozyme is present in lymphocytes 21) Lysozyme is thermally stable at the temperature up to 72 ℃ and at pH 5.0 22) Lysozyme plays an important role in immunology of infants 23) Opsonization – coating the phagocytes with proteins that facilitate phagocytosis 24) Macrophages are monocytes that move from the blood to tissues 25) M2 macrophages induce inflammation 26) Dendritic cells are present in those tissues that are in contact with the external environment 27) Dendritic cells process antigens and present them on the cell surface to the T cells 28) Neutrophils act mainly on viruses and parasites 29) Neutrophils are first responders to the sites of inflammation 30) Myeloperoxidase is an enzyme that is most abundantly present in the granules of neutrophils 31) Natural antibodies are important in preventing autoimmunity 32) Anti-microbial peptides (cationic and anionic proteins) exemplify the microbiological barrier 33) Antimicrobial peptides may act as immunomodulators 34) Myeloperoxidase enhances inflammation and apoptosis 35) Inflammation is a protective response involving immune cells, blood vessels, and molecular mediators 36) One of the functions of inflammation is to initiate tissue repair 37) Interleukins are cytokines that are produced and act on cells within all tissues 1 38) Macrophages secrete cytokines that attract other immune cells to the sites of inflammation 39) IL-8 is one of the inflammatory cytokines that are secreted by macrophages 40) IL-12 recruit NK cells 41) Toll-like receptors directly participate in phagocytosis 42) Toll-like receptors are expressed only on macrophages 43) NFkappaB is one of the most important genes that are activated by TLRs 44) Interferons can be released only by immune cells 45) Interferons may also be released in response to bacteria, parasites and tumor cells 46) IFN-α and IFN-β act mainly against viral infections 47) IFN-γ is critical for both innate and adaptive immunity 48) IFN-γ is an important activator of macrophages 49) NK do not require activation to kill their target cells 50) NK cells uniquely express CD3 marker 2
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