Science
Catholic Health Services of Long Island Molecular Biology Worsheet

Question Description

I’m working on a Biology exercise and need support.

please answer the three equation with detail and attach the references. if you don't know please don't try. I don't want to waste my time I have test

Unformatted Attachment Preview

Q1: Can we develop bifunctional small molecules that will couple oncoproteins or other cancercausing molecules of interest to inactivating processes such as degradation and achieve tissuespecific loss of function? Assignment: find in the literature or propose an approach to achieve tumor specific degradation of oncogenetic proteins Caveat: Cereblon and HIF1α are ubiquitously expressed Q2- How would you use pulse-chase approach to study RNA stability? Q3- which autophagy step(s) should be inhibitable by small molecules? ...
Purchase answer to see full attachment
Student has agreed that all tutoring, explanations, and answers provided by the tutor will be used to help in the learning process and in accordance with Studypool's honor code & terms of service.

Final Answer

Attached find the answer

1

Name
Course
Date
Question 1
Proteolysis Targeting Chimeras are heterobifunctional small molecules. As such, they act
as a link to the ligase system of E3 ubiquitin from the targeted protein. This leads to the
degradation of the targeted protein through the ubiquitin-proteasome system.
Consequently, the oncoproteins are inactivated using the bifunctional molecules that are
interconnected with the second moiety that is involved in the protein inactivation ("NCI's
Pro...

RKDEMASTER (2039)
University of Maryland

Anonymous
Top quality work from this tutor! I’ll be back!

Anonymous
Just what I needed… fantastic!

Anonymous
Use Studypool every time I am stuck with an assignment I need guidance.

Studypool
4.7
Trustpilot
4.5
Sitejabber
4.4