Science
Hormones that control hunger

Question Description

Can you help me understand this Biology question?

Can you elaborate a little on what researchers know about these three hormones?:  insulin, ghrelin and leptin.  A reference would be great!

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Final Answer

Leptin and ghrelin seem to be the big players in regulating appetite, which consequently influences body weight/fat. When we get hungrier, we tend to eat more. When we eat more, obviously, we maintain our body weight or gain that weight back.

Both leptin and ghrelin are peripheral signals with central effects. In other words, they’re secreted in other parts of the body (peripheral) but affect our brain (central).

Leptin is secreted primarily in fat cells, as well as the stomach, heart, placenta, and skeletal muscle. Leptin decreases hunger.

Ghrelin is secreted primarily in the lining of the stomach. Ghrelin increases hunger.

Leptin resistance is similar to insulin resistance (and they also share common signalling pathways). Insulin resistance occurs when there’s lots of insulin being produced (for example, with a diet high in sugar and simple carbohydrate), but the body and brain have stopped “listening” to insulin’s effects.

http://www.precisionnutrition.com/leptin-ghrelin-weight-loss


madhavant (2757)
UT Austin

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