Conversion of 5-FU to fluorodeoxyuridylic acid (FdUMP), communications homework help

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Question Description

39.1 A patient with colonic cancer is being treated with 5-FU as well as leucovorin (N5,N10-methylene tetrahydrofolate). The rationale for administering the coenzyme depends on it being essential for:

A. Conversion of 5-FU to fluorodeoxyuridylic acid (FdUMP).

B. Protection against the anemia caused by 5-FU treatment.

C. The inhibition of thymidylate synthase by FdUMP.

D. Prolongation of the antitumor effect of 5-FU

39.2 Neutropenia develops in a patient undergoing cancer chemotherapy. Administration of which one of the following agents would accelerate recovery of neutrophil counts?

A. Leucovorin.

B. Filgrastim.

C. Prednisone.

D. Vitamin B12.

39.3 Hydration and/or diuresis can prevent the renal toxicity associated with:

A. Cisplatin.

B. Chlorambucil.

C. Tamoxifen.

D. Gemcitabine.

E. MTX.

39.4 A patient is being treated with allopurinol to control hyperuricemia resulting from chemotherapy. Which of the following would have to have its dose reduced to prevent toxicity?

A. 5-FU.

B. 6-MP.

C. 6-TG.

D. Fludarabine.

E. Cytarabine.


Tutor Answer

Prof Major
School: UIUC

39.1 A patient with colonic cancer is being treated with 5-FU as well as leucovorin (N5,N10-methylene
tetrahydrofolate). The rationale for administering the coenzyme depends on it being essential for:
A. Conversion of 5-FU to fluorodeoxyuridylic acid (FdUMP).
B. Protection against the anemia caused by 5-FU treatment.
C. The inhibition of thymidylate synthase by FdUMP.
D. Prolongation of the antitumor effect of 5-FU.

Correct answer = C. Thymidylate synthase forms a ternary complex with thymidine and N5,N10methylene tet...

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