Substrate Level Phosophorylation and oxidative phosphorylation

timer Asked: Aug 28th, 2014
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Question Description

Can you outline and discussion Substrate Level Phosophorylation and oxidative phosphorylation?  A reference would be very helpful.

Tutor Answer

School: Purdue University

Substrate-level phosphorylation occurs during Glycolysis and the Kreb's Cycle and involves the physical addition 

of a free phosphate to ADP to form ATP. Oxidative phosphorylation, on the other hand, takes place along the 

electron transport chain, where ATP is synthesized indirectly from the creation of a proton gradient and the 

movement of these protons back accross the membrane through the protein channel, ATP synthase. As the 

protons pass through, ATP is created.

ReferenceLambeth,  Frohlich, Milavetz, BI (2004). "Expression of two succinyl-CoA synthetases with different nucleotide specificities .. The Journal of Biological Chemistry 279 (35): 36621–4. doi:10.1074/jbc.M406884200PMID 15234968

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