Metabolism, assignment help

Anonymous
timer Asked: Oct 8th, 2016
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Question description

3. Explain where in the CAC a hypothetical defect of an enzyme could occur that would decrease the overall ATP production of the mitochondria, including each of the following:

● whether the entire cycle will continue to function

● what will happen to the cycle products

● why ATP production decreases

Note: This is a hypothetical defect, so the explanation should not include descriptions of any known disease.



Tutor Answer

Raphael_M54
School: Purdue University

Here is the final answer. I got held up a bit and could have delivered it earlier.

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Citric Acid Cycle
Fumarase or Fumarate hydratase is an enzyme which catalyzes the reversible
hydration/dehydration of fumarate to S-malate. It comes in two forms which are mitochondrial
and cytosolic. The mitochondrial isoenzyme can be found in the Krebs cycle also known as
Citric Acid Cycle (CAC). Mitochondria are considered as energy-producing organelles as they
generate 90% of cellular ATP through the respiratory chain in the CAC (Grassian p.3317).
Mitochondrial defects then result to severe diseases that affect the whole orga...

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