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What are the three possible causes of linkage disequilibrium

Biology
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Summarize the logic behind Diaz et al.'s effort to establish the age of the 84GG allele in the Ashkenazim. What are the three possible causes of linkage disequilibrium?

Oct 31st, 2014

The logic is that if linkage disequilibrium is introduced by genetic drift, the two loci should gradually come back into equilibrium at a rate determined by the amount of crossing-over between the two locThe three possible causes of linkage disequilibrium are selection on multilocus genotypes, population admixture, and genetic drift. Selection was ruled out because one of the loci is selectively neutral, and population admixture was ruled out because the 84GG allele is not known to occur in other populations. However, it is possible that one of these two causes might be a factor - there might be a third linked locus, as yet unidentified that selection is acting on, or a now-vanished population might have contributed the 84GG allele. However, if selection is not a factor, the origin of 84GG can be calculated using the known rate of crossing-over to estimate the rate of decay of linkage disequilibrium. 

Reference:

www.life.umd.edu/.../Exam%202%20Study%20Questions%20(chap%20...



Oct 31st, 2014

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