Description
CC: “I have been having terrible chest and arm pain for the past 2 hours and I think I am having a heart attack.”
HPI: Mr. Hammond is a 57-year-old African American male who presents to the Emergency Department with a chief complaint of chest pain that radiates down his left arm. He states that he started having pain several hours ago and says the pain “it feels like an elephant is sitting on my chest”. He rates the pain as 8/10. Nothing has made the pain better or worse. He denies any previous episode of chest pain. Denies nausea, dyspnea, or lightheadedness. He was given 0.4 mg nitroglycerine tablet sublingual x 1 which decreased, but not stopped the pain.
Lipid panel reveals Total Cholesterol 324 mg/dl, high density lipoprotein (HDL) 31 mg/dl, Low Density Lipoprotein (LDL) 122 mg/dl, Triglycerides 402 mg/dl, Very Low-Density Lipoprotein (VLDL) 54 mg/dl
His diagnosis is an acute inferior wall myocardial infarction.
Why is HDL considered the “good” cholesterol?
2.CC: “I have been having terrible chest and arm pain for the past 2 hours and I think I am having a heart attack.”
HPI: Mr. Hammond is a 57-year-old African American male who presents to the Emergency Department with a chief complaint of chest pain that radiates down his left arm. He states that he started having pain several hours ago and says the pain “it feels like an elephant is sitting on my chest”. He rates the pain as 8/10. Nothing has made the pain better or worse. He denies any previous episode of chest pain. Denies nausea, dyspnea, or lightheadedness. He was given 0.4 mg nitroglycerine tablet sublingual x 1 which decreased, but not stopped the pain.
Lipid panel reveals Total Cholesterol 324 mg/dl, high density lipoprotein (HDL) 31 mg/dl, Low Density Lipoprotein (LDL) 122 mg/dl, Triglycerides 402 mg/dl, Very Low-Density Lipoprotein (VLDL) 54 mg/dl
His diagnosis is an acute inferior wall myocardial infarction.
Explain the role inflammation has in the development of atherosclerosis.
QUESTION 3

Explanation & Answer

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Pathophysiology
1. HDL is considered the good cholesterol since it has several beneficial properties that
protect against cardiovascular diseases. First, it collects excess cholesterol in the body
cells and transports it to the liver for excretion. HDL protects against the oxidative
damage of LDL at the site of arterial intima, thus inhibiting the production of proinflammatory cytokines. Moreover, HDL upregulates the expression of endothelial NO
synthase thus has atheroprotective function, as well as promotes EPCs-mediated
endothelial cell repair. HDL has also anti-thrombotic function through the
downregulation of thrombin generator and blunting of platelet activation. It provides
cyto-protection of endothelial cells by preventing their apoptosis.
-
Kosmas, C. E., Martinez, I., Sourlas, A., Bouza, K. V., Campos, F. N., Torres, V.,
Montan, P. D., & Guzman, E. (2018). High-density lipoprotein (HDL) functionality
and its relevance to atherosclerotic cardiovascular disease. Drugs in context, 7,
212525.
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Ben-Aicha, S., Badimon, L., & Vilahur, G. (2020). Advances in HDL: Much More
than Lipid Transporters. International journal of molecular sciences, 21(3), 732.
2. Inflammation plays a major role in all phases of atherosclerosis. Stable plaques are
characterized by a chronic inflammatory infiltrate, whereas active inflammation
contributes to vulnerable and ruptured plaque. Following endothelial damage, the
endothelium responds by recruitment of leukocytes, such as monocytes, macrophages,
dendritic cells and T cells into the intima. Immune cells then induce cytokine and
chemokine production, setting off the sequelae of the inflammatory response.
-
Sun, L., Zhang, W., Zhao, Y., Wang, F., Liu, S., Liu, L., Zhao, L., Lu, W., Li, M., &
Xu, Y. (2020). Dendritic Cells and T Cells, Partners in Atherogenesis and the
Translating Road Ahead. Frontiers in immunology, 11, 1456.
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Tay, C., Kanellakis, P., Hosseini, H., Cao, A., Toh, B. H., Bobik, A., & Kyaw, T.
(2020). B Cell and CD4 T Cell Interactions Promote Development of
Atherosclerosis. Frontiers in immunology, 10, 3046.
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Raggi, P., Genest, J., Giles, J. T., Rayner, K. J., Dwivedi, G., Beanlands, R. S., &
Gupta, M. (2018). Role of inflammation in the pathogenesis of atherosclerosis and
therapeutic interventions. Atherosclerosis, 276, 98–108.
3. An APRN can recognize the presence of a pleural friction rub according to the symptoms
and signs of the patient. Patients will often complain of pleuritic chest pain, which is
sudden, intense, and worse with movement such as respiration. They may be seen
tachycardic and taking rapid shallow breaths. Depending on the underlying etiology,
some may be relieved by leaning forward, others may complain of local tenderness upon
palpation. Palpation of the chest may note a sandpaper-rubbing type of sensation. On
auscultation, pleural friction rub is descried as walking on fresh ...
