Q11.1: Explain why a mutation in pyruvate carboxylase that blocks its ability to be regulated by acetyl-CoA results in lower rates of energy conversion via the Citrate Cycle. Hint: see figure 10.36. The Chemiosmotic Theory Q11.2: What was the biochemical reason for the "Ox Phos War," i.e., why was Peter Mitchell's hypothesis considered heretical? Mitochondrial Electron Transport Q11.3: What explains the observation that FADH2 oxidation yields one less ATP than NADH oxidation by the Electron Transport System? Q12.1: Why are 4 H+ needed for every ATP synthesized and exported by mitochondria, even though only 3 H+ need to be translocated by the ATP Synthase Complex to synthesize one ATP? Mitochondrial Shuttle Systems Q12.2: Explain why NADH synthesized in the cytosol of liver cells and used for mitochondrial energy conversion generates 2.5 ATP per NADH, whereas NADH synthesize in muscle cell cytosol only generates 1.5 ATP per NADH? Regulation of Oxidative Phosphorylation Q12.3: What is unusual about the genetically-inherited mitochondrial disease LHON as compared to the genetically-inherited disease sickle cell anemia? Discussion questions . . . Complete (6 points) All questions are answered All answers are complete All answers are correct All answers correctly address the questions asked All answers are well written using proper grammar and punctuation Partial (3 points) Not all questions are answered Not all answers are complete Not all answers are correct Some answers do not address the questions being asked No credit (O points) • No questions have been answered • All answers are incorrect • All answers do not address the questions being asked . . . Follow-up question . O Complete (2 points) Question is a logical extension of one of the discussion questions Question is in the student's own words Partial (1 point) Question is poorly written • Logic behind question is difficult to follow No credit (0 points) Question has been copied from another student • Question does not relate to one of the discussion questions • No question has been posed No credit (0 points) • Response is not thoughtful ("I liked the question because it was good.") • No response Response to a peer's question Complete (2 point) Response is thoughtful and clearly relates to the chosen question Chosen question is restated in student's response Response is well written using proper grammar and punctuation Partial (1 point) Response does not clearly address why a peer's question was chosen Response does not restate peer's question O .
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