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Coursework 2: 1500 word lab-based case study
Outline: Write a 1500 word case study, following the guidelines below. Clear guidance is
given on what you should include, and further areas for consideration were provided in the
case-study material provided via Blackboard. The case study is designed to give a realistic
overview of a single breast cancer patient from screening, through diagnosis, to the gathering
of prognostic information and treatment schedule. It is your understanding of this process,
and the interpretation of Cellular Pathology-derived data that will be assessed.
Content and structure:
You do NOT need to repeat the patient-specific information given in the case study
documentation in your report – this will not gain you marks. You will, however, need to apply
a narrative to your report. The following guidelines should help with this. Particular areas are
covered in this guidance, and/or specific questions posed for you to answer – however, in the
interests of developing your writing skills, do NOT use these directly as subheadings in your
report. See notes below on subheadings.
Consider including the following points: (every point needs justification)
• Initial diagnosis
1. Briefly describe the principle of mammography and how a “suspicious mass” is
2. What conclusions can be drawn from the needle biopsy?
3. What are the limitations of the needle biopsy?
• Include labelled images from the practical class (not the case study
documentation) to illustrate your answers to the following section with
appropriate figure legends.
1. Why do we need to determine the histological subtype of tumour?
2. How would the molecular characteristics of the tumour determine the treatment
regimen AND prognosis?
3. Please grade the tumour that you have studied and explain your reasoning.
4. Please provide a TNM stage for this case based on the data that you have available,
and discuss any limiting factors.
5. What is the clinical prognosis for Diana? Include in your answer an indication of her
percentage chance of being alive 5 years after this diagnosis and explain your
6. Based on everything that you now know about this case, what treatment is Diana likely
7. What clinical trials are currently running in the UK that may be appropriate for Diana
to participate in? Include in your answer a brief description of the mechanism of action
for this treatment and your rationale for it being suitable for Diana.
Information on Presentation
Use of subheadings (ACTIVE SUB-HEADINGS NEEDED)
Subheadings are a powerful tool when writing, and some thought should be given to their use.
They can be used to reinforce a narrative structure to your work, but can also be used to
disarm a readers preconceptions. Subheadings that make active statements are much more
effective than passive ones. For example:
“Subtypes of breast cancer” = passive
“Breast cancer presents as a number of different subtypes – each having a different treatment
regimen” = active
Referencing: Minimum 20 UWE Harvard references (USING THIS GENERATORhttps://app.bibguru.com/p/50e5891c-40f0-4d07-97d7-060d131aa495 )
Word limit: 1500 words (excluding references and figure legends) is the LIMIT for this
assignment. Your word count should be indicated clearly on the first page. Overly long figure
legends will not receive marks.
Learning Outcomes Addressed
Employ good laboratory practice related to Cellular Pathology techniques.
Understand the principles of tissue preparation for histology and the mechanism by
which common staining methods work.
Discuss the role of Cell Pathology in the diagnosis and prognosis of both neoplastic
and non-neoplastic disease in the major organs and tissues.
Understand current therapeutic approaches and be able to discuss potential future
avenues for therapy.
Your assignment will be marked in-line with the Faculty of Health and Applied Science’s
marking criteria, which are provided on the next page.
*FHEQ Level 5
Level 2 Limited/ Exceptionally
Limited Piece of Work
Marginal Fail/ Limited
piece of work
Some evidence of
overall not reaching
the minimum pass
standard due to some
key omissions in
argument or structure.
Lines of argument
not always relevant.
Limited evidence of
Some evidence of
effort but missing
aspects. For example,
may be lacking in
and structure. Likely to
discussion with some
lack of relevance.
need to be improved.
Likely to show
analysis is not
g of key
but not always
focus may need
Paste module LO’s in this
some irrelevant or
Lack of discussion.
Likely to show
of reading. Likely to be
deficiencies. Likely to
irrelevant or incorrect
material. Likely to
have very poor
structure and no
evidence of sufficient
Zero is reserved for
failure to attempt an
answer but where a
submission has been
generally sound with
some evidence of
usually clear but
may need to
analysis could be
of reading but could
have read more
A maturing ability to
relate theory and
always relevant and
but may be limited
Some evidence of
having drawn on
beyond the course