assisting in microbiology and immunology

Health & Medical
Tutor: None Selected Time limit: 1 Day

explain helminths and assessing a cuture

Dec 22nd, 2014

HELMINTH INFECTION AND COGNITIVE IMPAIRMENT AMONG FILIPINO CHILDREN

  1. AMARA E. EZEAMAMA*
  2. JENNIFER F. FRIEDMAN*
  3. LUZ P. ACOSTA,
  4. DAVID C. BELLINGER
  5. GRETCHEN C. LANGDON
  6. DARIA L. MANALO,
  7. REMIGIO M. OLVEDA
  8. JONATHAN D. KURTIS and 
  9. STEPHEN T. MCGARVEY

+Author Affiliations

  1. International Health Institute, Brown University, Providence, Rhode Island; Research Institute of Tropical Medicine, Manila, The Philippines; Department of Environmental Health, Children’s Hospital, Boston, Massachusetts

Abstract

The objective of this study was to examine the independent effect of infection with each of four helminths (Ascaris lumbricoidesSchistosoma japonicum,Necator americanus, and Trichuris trichiura) on cognitive function after adjusting for the potential confounders nutritional status, socioeconomic status (SES), hemoglobin, sex, and the presence of other helminthes. This cross-sectional study was carried out in a rural village in Leyte, The Philippines in 319 children 7–18 years old. Three stools were collected and read in duplicate by the Kato Katz method. Infection intensity was defined by World Health Organization criteria. Cognitive tests were culturally adapted and translated. Learning and memory cognitive domains were each defined by three subscales of the Wide Range Assessment of Memory and Learning, which had an inter-rater reliability ≥ 0.92 and test-retest reliabilities ranging from 0.61 to 0.89. A household SES questionnaire was administered. A logistic regression model was used to quantify the association between performance in different cognitive domains (learning, memory, verbal fluency, and the Philippine Non-Verbal Intelligence Test) and helminth infections. After adjusting for age, sex, nutritional status, hemoglobin, and SES, S. japonicum infection was associated with poor performance on tests of learning (odds ratio [OR] = 3.04, 95% confidence interval [CI] = 1.1–6.9), A. lumbricoides infection was associated with poor performance on tests of memory (OR = 2.2, 95% CI = 1.04–4.7), andT. trichiura infection was associated with poor performance on tests of verbal fluency (OR = 4.5, 95% CI = 1.04–30). Helminth infection was associated with lower performance in three of the four cognitive domains examined in this study. These relationships remained after rigorous control for other helminths and important confounding covariates.

  • Received June 21, 2004.
  • Accepted July 26, 2004.
  • Copyright 2005 The American Society of Tropical Medicine
http://www.ajtmh.org/content/72/5/540.short 


Dec 22nd, 2014

Did you know? You can earn $20 for every friend you invite to Studypool!
Click here to
Refer a Friend
...
Dec 22nd, 2014
...
Dec 22nd, 2014
Dec 9th, 2016
check_circle
Mark as Final Answer
check_circle
Unmark as Final Answer
check_circle
Final Answer

Secure Information

Content will be erased after question is completed.

check_circle
Final Answer