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When do B-cells differentiate?

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When do B-cells differentiate?

Oct 18th, 2017

Once a B cell encounters its cognate antigen and receives an additional signal from a T helper cell, it can further differentiate into one of the two types of B cells: plasma B cells and memory B cells. The B cell may either become one of these cell types directly or undergo an intermediate differentiation step, the germinal center reaction, where the B cell will hypermutate the variable region of its immunoglobulin gene ("somatic hypermutation") and possibly undergo class switching. Other functions for B cells include antigen presentation, cytokine production, and lymphoid tissue organization.

Reference:

http://en.wikipedia.org/wiki/B_cell


Dec 28th, 2014

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