ASU Inflammasome Link to Maternal and Neonatal Death in Viral Pregnancy Essay

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essay on Inflammasome and its potential link with maternal mortality rate and Neonatal Death in viral pregnancy

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Inflammasome Link to Maternal and Neonatal Death in Viral Pregnancy.

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Introduction
Inflammasomes are cytoplasmic multiprotein elements that signal inflammatory
reactions, including those that happen during pregnancy. The gestational tissues produce
inflammasomes and their downstream mediators' caspase-1 and IL-B, that is, the placenta and
chorioamnionitis membranes (Ferreira, 2021). In addition, inflammasomes initiate key processes
during host protection against microorganisms and immunoregulation (Hantoushzadeh, 2020). In
pregnancy, the immune system adapts to various mechanisms to support fetal growth and protect
the mother from infections.
Discussion
Epidemiological reports acquired from previous pandemics, like flu and ebola,
demonstrate that pregnant mothers are increasingly vulnerable to viral infection and its
complications, including death (Rodriguez, 2021). In addition, physiological changes in the
physical anatomy of the respiratory system and the immunological mechanisms during the
pregnancy-puerperal period appear to add to the risk of infection (Iqbal, 2020). In this way,
pregnant mothers are more vulnerable to infection by the SARS-COV-2 or other diseases and
complications of COVID-19. The COVID-19 virus alters immune responses at the maternal-fetal
interface, leading to the ill health of both the mother and her offspring. Unfortunately, there is
still no adequate evidence in writing to help the event of vertical transmission and through
breastfeeding, yet the prevalence of premature births was high among SARS-Cov-2 infected
mothers (Giles, 2020).
During pregnancy, the immune system undergoes specific changes that evade an
exacerbated immunological reaction against the allogeneic embryo yet maint...

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