Description
please let it be in word format
Explanation & Answer
Attached.
D.I.C (Disseminated Intravascular Coagulopathy)
Specific Learning Objectives
•
Understand pregnancy as a hypercoagulable state
•
Understand the pathophysiology of DIC
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List obstetric conditions associated with DIC
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Describe clinical features associated with DIC
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List complications associated with DIC
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Describe the management of DIC
Pathophysiology of DIC
Def: A condition associated with inappropriate activation of
coagulation & fibrinolytic systems.
1
Physiology of coagulation cascade mechanism
XII- Hageman factor, a serine protease
XI –Plasma thromboplastin, antecedent serine protease
IX – Christmas factor, a serine protease
VII – Stable factor, serine protease
VIII – Fibrin stabilizing factor, a transglutaminase
IV (PL) – Platelet membrane phospholipid
Ca++- Calcium ions
TF –Tissue factor
2
Physiology of coagulation cascade mechanism
Thrombin – Proteolytic enzyme:
• Splits fibrinogen chains into fibrinoid peptides leading
• Formation of fibrin monomer
NB: Activation of coagulation system:
• Stimulates conversion of plasminogen into plasmin as
• Protective mechanism against intravascular thrombosis
Plasmin
• Inactivates factors V & VIII
• Lyses fibrin & fibrinogen to form degradation products
Thus, normal physiologic haemostasis represents a delicate & complex
balance between coagulation & fibrinolytic systems
Pregnancy Changes
Pregnancy represents a hypercoagulable state
• Overall increased activity of coagulation factors except XI & XII...