juvenile dermatomyositis, health and medicine homework help

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Question Description

short notes on the above. can be in power point or word

Tutor Answer

nancyW
School: UCLA

Attached.

Scleroderma

Scleroderma
derived from greek and means
hard skin
Affects about 250/million =
7500 Canadians
Affects mainly women in the
prime of their life (women:men ratio 35:1, onset between 30-50 years)

SYSTEMIC SCLEROSIS OR
SCLERODERMA
A generalized disorder of connective
tissue characterized clinically by:
thickening and fibrosis of the
skin (scleroderma)
 distinctive forms of
involvement of internal organs,
notably the heart, lungs,
kidneys, and gastrointestinal
tract.

ACR CRITERIA
Sclerodermatous skin change in any location
proximal to the metacarpophalangeal joints
The presence of two or more of the following
features contributed further as minor criteria:
sclerodactyly
pitting scars of fingertips or loss of digital finger pad
substance
 bibasilar pulmonary fibrosis

Raynaud’s
Phenomenon

Skin thickening of systemic sclerosis begins
on the fingers and hands in nearly all
cases. The skin initially appears shiny and
taut and may be erythematous at early
stages.

Phases of skin thickening
 Edematous

Causes of this swelling
Basically this is water in the tissues = edema

Binding of water to increased extracellular
connective tissue matrix
Inflammation

Poor lymphatic return
Microvascular injury with fluid extravasation

Indurative Phase

 Thick

 Shiny
 Taught
 Tightly adheres to underlying tissue so cannot be easily picked up
 Creases disappear

 May become hyper- or hypo-pigmented
 Hair loss
 Decreased sweating

Facial changes
Pinched nose
(“mauskopf”)
Pursed lips
...

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Anonymous
Thanks, good work

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