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Bleeding disorders
kibaru

introduction
 Hemophilia is characterized by spontaneous bleeding manifested by
hemarthrosis, surgical/trauma bleeds, intracranial hemorrhage, and
intramuscular bleeds.
 ▪

The clinical severity of hemophilia depends on factor VIII or IX level.

 ▪ Treatment of hemophilia requires prompt recombinant factor
replacement.

 ▪ von Willebrand disease (vWD) is the most common
inherited bleeding disorder.




▪ vWD is caused by either a quantitative or qualitative
defect of the von Willebrand factor (vWF) protein.

 ▪ Idiopathic thrombocytopenia purpura (ITP) is a
diagnosis of exclusion from a long list of causes of
thrombocytopenia.

 ▪ Disseminated intravascular coagulation (DIC) is always
secondary to an underlying disorder.
 ▪ The key therapeutic approach to DIC is treatment of the
underlying disease

HEMOPHILIA
 Inherited deficiency of factor VIII
(hemophilia A) or factor IX (hemophilia
B)
 Sex-linked inheritance; almost all
patients male
Female carriers may have mild symptoms

 Hemophilia A
�...


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