owerpoints on barbiturate poisoning, health and medicine homework help

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make powerpoints on barbiturate poisoning

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Barbiturate poisoning

Babiturate poisoning
• Substituted derivative of barbituric acid (derived from ureamalonic acid)
• Classification
– Long
• Barbital, Phenobarbital

– Intermediate
• Amo barbital, Buta barbital

– Short
• Pento barbital
• Seco barbital

– Ultra short
• Thio pental
• Methohexital

Mechanism of action

• Acts at GABA-BZD receptor - Cl- channel complex
• Potentiate GABAnergic inhibition by increasing life time of Cl- channel
opening
• Increased conc. barbiturate   Cl- conductance  depress Na+/K+
channels

Properties
Long

Pka

Inter

Short

Ultrashort

Barbital

Pheno
barbital

Amo

Buta

Pento

Seco

Thio

Metho

7.74

7.25

7.7

7.74

7.96

7.9

7.6

7.9

Detoxification

Renal

Renal

Hepatic

Hepatic

3-6

6

>6

Half life
(hr)

X

24-140

8-42

34-42

21-42

20-28

6-46

1-2

Fatal
dose
(gm)

10

5

X

X

3...


Anonymous
Very useful material for studying!

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