Description
.heart disease remains the No. 1 killer in America; nearly half of all Americans have high blood pressure, high cholesterol, or smoke—some of the leading risk factors for heart disease…
—Murphy et al., 2018
Despite the high mortality rates associated with cardiovascular disorders, improved treatment options do exist that can help address those risk factors that afflict the majority of the population today.
Photo Credit: Getty Images/Science Photo Library RF
As an advanced practice nurse, it is your responsibility to recommend appropriate treatment options for patients with cardiovascular disorders. To ensure the safety and effectiveness of drug therapy, advanced practice nurses must consider aspects that might influence pharmacokinetic and pharmacodynamic processes such as medical history, other drugs currently prescribed, and individual patient factors.
Reference: Murphy, S. L., Xu, J., Kochanek, K. D., & Arias, E. (2018). Mortality in the United States, 2017. Retrieved from https://www.cdc.gov/nchs/products/databriefs/db328...
To Prepare
Review the Resources for this module and consider the impact of potential pharmacotherapeutics for cardiovascular disorders introduced in the media piece.
Review the case study assigned by your Instructor for this Assignment.
Select one the following factors: genetics, gender, ethnicity, age, or behavior factors.
Reflect on how the factor you selected might influence the patient’s pharmacokinetic and pharmacodynamic processes.
Consider how changes in the pharmacokinetic and pharmacodynamic processes might impact the patient’s recommended drug therapy.
Think about how you might improve the patient’s drug therapy plan based on the pharmacokinetic and pharmacodynamic changes. Reflect on whether you would modify the current drug treatment or provide an alternative treatment option for the patient.
By Day 7 of Week 2
- Write a 2- to 3-page paper that addresses the following:
- Explain how the factor you selected might influence the pharmacokinetic and pharmacodynamic processes in the patient from the case study you were assigned.
- Describe how changes in the processes might impact the patient’s recommended drug therapy. Be specific and provide examples.
- Explain how you might improve the patient’s drug therapy plan and explain why you would make these recommended improvements.
This week, you will examine the impact of patient factors that may lead to changes in pharmacokinetic and pharmacodynamic processes on patient drug therapy for cardiovascular disorders. You will also explore ways to improve drug therapy plans for cardiovascular disorders based on patient factors and overall health needs.
Students will:
- Analyze the influence of patient factors on pharmacokinetic and pharmacodynamic processes
- Analyze the impact of changes in pharmacokinetic and pharmacodynamic processes on patient drug therapies
- Evaluate drug therapy plans for cardiovascular disorders
Patient CB has a history of strokes. The patient has been diagnosed with type 2 diabetes, hypertension, and hyperlipidemia. Drugs currently prescribed include the following:
- Glipizide 10 mg po daily
- HCTZ 25 mg daily
- Atenolol 25 mg po daily
- Hydralazine 25 mg qid
- Simvastatin 80 mg daily
- Verapamil 180 mg CD daily
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Explanation & Answer

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Pharmacotherapy for Cardiovascular Disorders Outline
Thesis statement: In the United States, Diabetes is the 7thleading cause of death that is usually
linked with comorbidities like stroke, heart attack, kidney disease, hypertension, and
cardiovascular disease. Notably, in this case study my patient will be aged 63 years and will be
an African-American.
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Ethnicity as the factor that influence the pharmacokinetic and pharmacodynamics process
in the patient from the case study.
•
The various ways the changes might affect the patient’s recommended drug therapy.
•
The various ways I might improve the patient’s drug therapy plan and my explanations
why I would make these recommended improvements.
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Pharmacotherapy for Cardiovascular Disorders
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Professor
Institution
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Pharmacotherapy for Cardiovascular Disorders
In the United States, Diabetes is the 7thleading cause of death that is usually linked with
comorbidities like stroke, heart attack, kidney disease, hypertension, and cardiovascular disease.
It is worth noting that Africans-Americans have a higher probability of obesity, stroke,
cardiovascular disease, and hypertension than other ethnicit...
