Abnormalities of Electrolytes

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Abnormalities of Electrolytes
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objectives
By the end of the session the student
should be able to
◦ Outline the common electrolytes, etiology
of excess or deficiency and treatment

Potassium
 Potassium

is mostly contained in the
intracellular compartment.

 serum

potassium levels do not indicate the
total body potassium accurately.

 Blood

pH levels affect the
distribution of potassium
between the intracellular and
extra cellular compartments.

A

low pH shifts potassium out of the cell,
while alkalosis drives potassium into the
cell.

A

handy rule is that each 0.1 unit change
in pH results in a 0.3-0.6mEq/L change in
serum potassium.

 The

intracellular potassium concentration
affects cellular enzymes and intracellular pH.



Low intracellular potassium raises the pH,
whereas high intracellular potassium lowers
the pH.

 Potassium

is necessary for maintaining cell
volume because of its important contribution
to intracellular osmolality

 Potassium

is plentiful in food.
 Dietary consumption varies
 1–2 mEq/kg is the recommended
intake.

 The

intestines normally absorb approximately
90% of ingested potassium.



Most absorption occurs in the small intestine,
whereas the colon exchanges body potassium
for luminal sodium

 There

is some loss of potassium in sweat,
but this is normally minimal.

 The

colon has the ability to eliminate
some potassium.

 Potassium


is freely filtered at the glomerulus

90% is reabsorbed before the distal tubule
and collecting duct, the principal sites of
potassium regulation.

Hypokalemia
 Hypokalemia

is defined as a serum
potassium level of < 3.5mEq/L.

 Hypokalemia

often results from
chronic diuretic use



unreplaced electrolyte loss from NG
drainage.

CAUSES
TRANSCELLULAR SHIFTS
▪ Alkalemia
▪ Insu...


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