Specific mechanisms that keep healthy cells in check in the cell cycle

Biology
Tutor: None Selected Time limit: 1 Day

"Much time is spent in Ch. 12 of the textbook on loss of cell cycle control, leading to a malignant cancerous state. Describe at least two ways that normal, healthy cells keep the cell cycle in check. There are multiple ways that this occurs, so there are a lot of possibilities for your answer here. Explain how your chosen mechanisms work to keep cells from multiplying out of control." what kind of mechanisms is he referring to?  G1 and such or density-dependent inhibition?

Mar 29th, 2015

A way normal cells keep themselves intact is anchorage dependence. In order to divide, the cells must be attached to a substratum, such as the inside of a culture flask or the extracellular matrix of a tissue. This is one of the main systems in place to prevent cells from going out of control.

Another measure to prevent the growth of cancerous cells would be density-dependent inhibition, a phenomenon in which crowded cells stop dividing. Cultured cells normal divide until they form a single layer of cells on the inner surface of the culture flask, at which point the cells stop dividing. IF some cells are removed, those bordering the opening will continue to divide until the space is filled. 


(PS. please tell me if this answers the question, there are many more ways. If these are not satisfactory, I will be happy to add more, just contact me ASAP).

Thanks 

Mar 29th, 2015

That is exactly what I wanted to know!  Thank you so much for your help!  I appreciate it!  


Also, "In Ch. 11, I gave you the example of apoptosis as a mechanism of signal transduction. Find an example of another signal transduction pathway, and explain it to me (you can NOT choose any of the additional specific examples characterized in your textbook, however). It could be from a plant, an animal, even a bacterial cell. Remember to characterize it in terms of the 3 main aspects: reception, transduction, and response."

So, what are some examples of a mechanism of single transduction?


Mar 29th, 2015

um, would cyclin-dependent kinases count as a signal transduction, I don't know if it is in your book.


Mar 29th, 2015

Are you using `Campbell biology ? 10th edition 

Mar 29th, 2015

Well, if you are chapter 12 has an example of a growth factor called platelet-derived growth factor. 

Honestly, I don't know any examples that were used outside of the text.

The fibroblasts sustain the PDGF receptor on their plasma membrane. The binding of PDGF molecules to these receptors will trigger a signal transduction pathway that allows the cells to pass the G1 checkpoint and divide. PDGF stimulates fibroblast division not only in the artificial conditions of cell culture, but also in an animals body. For instance, when injury occurs, platelets release PDGF. The resulting proliferation of fibroblasts help heal the wound. 


Mar 29th, 2015

I am using Campbell Biology 10th edition, and everything I can think of was used as an example in the book.  That is why I am struggling to find an answer to the essay prompt....

Mar 29th, 2015

Alright, use the promocode "Joshua S" for additional fundature.


Mar 29th, 2015

Actually, I think I found one that is not in the book.

neurotrophin growth factor , can you check to see if that is in the book? 

Mar 29th, 2015

It's not in the book!  Thank you so much for your assistance! 

Mar 29th, 2015

http://www.ncbi.nlm.nih.gov/books/NBK10990/

Use that link for more information 

Mar 29th, 2015

Thanks!

Mar 29th, 2015

anytime, remember to use the promocode(you get $10) if you want to ask more questions.

I also get $10, so..win win 


Mar 29th, 2015

IF you use it, I will give you discount on bio questions. 

Mar 29th, 2015

Are you studying on the go? Check out our FREE app and post questions on the fly!
Download on the
App Store
...
Mar 29th, 2015
...
Mar 29th, 2015
Dec 9th, 2016
check_circle
Mark as Final Answer
check_circle
Unmark as Final Answer
check_circle
Final Answer

Secure Information

Content will be erased after question is completed.

check_circle
Final Answer