Gentamicin Antibiotics Paper

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Description

  1. This is an independent research paper on an antibiotic selected by you or with assistance from the professor. Your topic must be approved by the professor. This assignment is must be done for 5 pages . The paper should include:
  1. An introduction to the discovery of the drug
  2. The mechanism of action
  3. The synthesis of the drug
  4. The clinical applications and indications
  5. Discussion of resistance issues.Begin developing ideas for a final paper topic.

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Major Assignment 1 - Paper Grading Rubric (THIS RUBRIC WILL GIVE A % GRADE ON THE ASSIGNMENT WHICH WILL BE INCOORPERATED INTO YOUR COURSE GRADE AS A % OF THE 250 COURSE POINTS ALLOCATED TO THIS ASSIGNMENT) Name: Course: CHEM05530 CATEGORY Unacceptable (Below Standards) Acceptable (Meets Standards) Good (Occasionally Exceeds) Excellent (Exceeds Standards) Introduction / Background / Discovery Does not adequately convey topic. Does not describe subtopics to be reviewed. (0 points) Conveys topic, but not key question(s). Describes subtopics to be reviewed. ( 1 0 points) Conveys topic and key question(s). Clearly delineates subtopics to be reviewed. ( 2 0 points) Confusing or absent description of synthetic routes. Inadequate outline of purification techniques. (0 points) Superficial description of synthetic routes and purification techniques. (20 points) Description of synthetic routes. Outline of purification techniques. (30 points) Strong introduction of topic’s key question(s), terms. Clearly delineates subtopics to be reviewed. ( 3 0 points) Clear description of synthetic routes. Thorough, systematic outline of purification techniques. (40 points) Unclear, incomplete or absent descriptions of how the drug works and how resistance develops. (0 points) General descriptions of how the drug works and how resistance develops. (40 points) Mechanistic descriptions of how the drug works and how resistance develops. (60 points) Clear, detailed, mechanistic descriptions of how the drug works and how resistance develops. (80 points) 80 points The application of the compound is discussed but is unclear and incomplete. (0 points) Review of key applications. Some discussion of impact of the application of the compound. (20 points) Good review of key applications. Discussion of impact of the application of the compound. (30 points) Strong review of key applications. Insightful discussion of impact of the application of the compound. (40 points) 40 points A significant number of aspects missing. (0 points) A few aspects of market analysis are missing; unclear outlook. (20 points) A few aspects of market analysis are missing, but does not detract from overall message. (30 points) 40 points Few sources supporting thesis. Sources insignificant or unsubstantiated. Incorrect format (0 points) Sources generally acceptable but not peer-reviewed research (evidence) based. Some errors in format (10 points) Sources well selected to support thesis with some research in support of thesis. Mostly correct format (15 points) The paper is completely outlines current and future market prospects. (40 points) Strong peerreviewed research based support for thesis. Correct format. (20 points) Synthesis & Purification Mechanism of Action / Resistance Applications Market Analysis Citations & References Comments: Total Points: SCORE 30 points 40 points 20 points
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Outline
Introduction
Gentamicin is a broad spectrum and belongs to the group of aminoglycoside antibiotics.
The key questions and terms include the definition of gentamicin, uses, mechanism of action,
application, market analysis, and synthesis. Are there adverse effects of the drug, who should use
it, and what should it be used for in healthcare? The paper will explore these questions to provide
meaningful information that is appropriate for all readers.
Mechanism of Action
Gentamicin has a bactericidal activity; thus, it binds to the bacteria ribosomal 30S subunit. The
entry into the cell involves three phases.
Synthesis and purification
Gentamicin is produced by fermentation from Micromonospora purpurea. It is then supplied to a
mixture comprised of gentamicin C1, C1a, C2, C2a, and C2b. Gentamicin is collected by
perforating the bacterial cell wall.
Application
Gentamicin injection is used for serious bacterial injections; these include infections of the
blood, skin, lungs, and joints. Gentamicin drug dosage depends on medical condition and response
to treatment; the drug is injected into the muscle or a vein intravenously.


Running head: GENTAMICIN

1

Gentamicin Antibiotics
Name
Course Code
Date

Running head: GENTAMICIN

2

Introduction
Gentamicin is a broad spectrum and belongs to the group of aminoglycoside antibiotics.
The key questions and terms include the definition of gentamicin, uses, mechanism of action,
application, market analysis, and synthesis. Are there adverse effects of the drug, who should use
it, and what should it be used for in healthcare? The paper will explore these questions to provide
meaningful information that is appropriate for all readers.
Gentamicin is a drug that acts against positive and gram-negative rod bacteria. It works by
killing bacteria or preventing bacterial growth. Weinstein, Wagman, et al. discovered the drug in
1963. The fermentation of Micromonospora purpurea produces it. Gentamicin has bactericidal
activity, making it a good option for treating several common bacterial infections.
The drug remains popular because of its low cost, low antimicrobial resistance, and is quite an
effective antibiotic. Gentamicin does not work for flu, viral infections, or cold. Instead, gentamicin
treats infections such as endocarditis, pelvic inflammatory disease, pneumonia, urinal tract
infection, and sepsis.
There is synergistic activity when gentamicin is...


Anonymous
I was struggling with this subject, and this helped me a ton!

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