Pen/fine tip marker
Colored pencils or colored fine tip markers
Activity 1: Construct the Major Endocrine Pathways—Normal Function
1. Draw the glands involved in the TWO major endocrine pathways, starting with the hypothalamus in the order they appear in the body (hint: use a diagram in the lecture to guide you). You can draw each pathway separately on two pieces of paper or on each side of one piece, or you can draw them all on one piece of paper and show how they are connected:
a. Thyroid pathway—hypothalamus-pituitary-thyroid
b. Adrenal pathway—hypothalamus-pituitary-adrenal
2. Draw arrows to indicate the directions of hormone signaling in the pathways (i.e. which gland stimulates which gland to secrete a hormone; which gland stimulates which gland to STOP secreting a hormone.
3. Label each arrow with a (+) or (-) sign to indicate whether the hormone is sending a positive (increase secretion) or negative (decrease secretion) signal.
Activity 2: Hormones
1. Use a BLUE colored pencil or marker to write the hormones that are secreted by each gland next to or in the gland—write one per line (e.g. TSH
2. Write with BLUE pencil in the margin or a separate piece of paper, the function of each hormone (i.e. what it regulates, what its action is, etc.)
Activity 3: Altered Endocrine Function
I. Pituitary Adenoma (Tumor) [NOTE: What are the most COMMON alterations?]
1. Use a GREEN colored pencil to draw a tumor on the pituitary gland
2. Draw GREEN arrows by the hormones secreted by the each gland in the pituitary pathway to indicate whether hormones will most likely increase (UP arrows) or decrease (DOWN arrows)
3. Write with GREEN pencil in the margin or a separate piece of paper, the effects of each change in levels of affected hormones in the pathway (what symptoms will the patient have?)
II. Graves Disease
1. Use a RED pencil or marker to make a mark on the thyroid gland to indicate Graves Disease
2. Draw RED arrows by the hormones in the affected pathway to indicate whether hormones will increase (up arrows) or decrease (down arrows)
3. Write with RED pencil in the margin or a separate piece of paper, the effects of each change in levels of affected hormones in the pathway
A. Primary Hypothyroidism:
1. Draw PURPLE arrows to indicate what hormones increase and/or decrease in primary hypothyroidism
2. Write with PURPLE pencil in the margin or a separate piece of paper, the effects of each change in levels of affected hormones in the pathway.