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Biology
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What is the difference between gate-keeper and care-taker genes. Provide a specific example of how each gene type works to prevent cancer. 

Apr 13th, 2015

Caretaker genes encode items that balance out the genome. In a broad sense, changes in guardian qualities lead to genomic precariousness. Tumor cells emerge from two unmistakable classes of genomic shakiness: mutational flimsiness emerging from changes in the nucleotide arrangement of DNA and chromosomal unsteadiness emerging from despicable modification of chromosomes.

Gatekeeper genes are proteins that straightforwardly control the cell cycle. As juxtaposed to caretaker genes  that in a roundabout way prompt malignancy by permitting collection of changes, a change in a gatekeeper (of both its alleles) will straightforwardly prompt tumor by permitting uncontrolled cell development. They in a roundabout way counteract transformations by ending the cell cycle if DNA is harmed, fortifying its reparation.

In addition to their anti-cancer functions, gatekeeper and caretaker genes have been known to have an effect on senescence, especially later in life. Gatekeepers may induce aging, and caretakers are known to maintain telomeres. Dysfunctional gatekeepers and caretakers may thus lead not only to cancer but also to premature aging.

Specific examples of gatekeeper genes (Rb, BRCA and APC). Two examples are MLH1/MSH2, which are involved in DNA mismatch repair, and XP-A, which is involved in the nucleotide excision repair pathway (2,3).

http://www.nature.com/scitable/content/cancer-genes-and-the-pathways-they-control-14019136


Apr 13th, 2015

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