Paediatrics medicine Chronic Renal Failure

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CHRONIC RENAL FAILURE

Chronic

renal failure (CRF)
is defined as an irreversible
reduction in GFR.

 The

prevalence of CRF in the
pediatric population is
approximately 18 per 1
million.



The prognosis for the infant, child, or
adolescent with CRF has improved
dramatically over the past 4 decades
because of improvements in medical
management






aggressive nutritional support
recombinant erythropoietin
recombinant growth hormone
, dialysis techniques
renal transplantation.

Etiology


In children, CRF may be the result of







Congenital
acquired
inherited
metabolic renal disease

the underlying cause correlates closely
with the age of the patient at the time
when the CRF is first detected.



CRF in children younger than 5 yr is most
commonly a result of congenital
abnormalities such as renal hypoplasia,
dysplasia, and/or obstructive uropathy.

After 5 yr of age
 acquired diseases (various forms of
glomerulonep...


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