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I want someone to write 8 pages about Glycoconjugate: A,C,W,Y; carrier proteins, how sugars are obtained, conjugation chemistry. (write the references please).
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Glycoconjugate
This is the classification for different chemicals species that are linked with
carbohydrates covalently. The species include peptides, lipids proteins, and the saccharides. This
is formed through the process called glycosylation. These are the vaccines that are considered to
be more effective and safe than ever introduced. In the vaccine, diphtheria toxoid, CRM, and the
tetanus toxoid are the ones used mostly as the proteins carriers in any vaccines that are licensed.
These vaccines are also made of the antigens of carbohydrates and they are covalently bound to
the carrier of protein and this is to enhance their immunogenicity. According to the different
clinic studies, five of the protein carriers have been used for the licensed vaccines (Bröker et al.,
n.d).
The main role of the carrier in the glycoconjugate as a vaccine is the provision of the
epitomes of the T-cell which subsequently puts together the class II MHC and this is done in the
service of the cells that are presenting the antigens. MHC II also has a high affinity which binds
the peptides and other factors that are processed in the antigen like glycoconjugate (Tontini et al.
n.d.).
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Being the most effective and safe and one way of encapsulated prevention and other
infections and mortality, this vaccine provides the t-cell epitomes that produce an independent
character saccharide moiety. There are five carrier proteins currently which include the vaccine
that is licensed and they are called the glycol-conjugate. The toxics of tetanus and diphtheria are
also derived from the toxins respectively, this is after the detoxification of various chemicals
with the formaldehyde, initial this is selected as the carriers due to the safety record that is
accumulated with diphtheria and tetanus vaccination. Diphtheria has a non-toxic mutant that is
called CRM which has been extensive as a carrier for the conjugate vaccines that are licensed
and this done against the type b of haemophilus influenza, Neisseria meningitides, Streptococcus
pneumonia and other clinical development vaccines. Another carrier is the outer membrane
protein complex which is serogroup B of the N. meningitides, which is used as a carrier of the
Hib conjugate vaccine that was established by Merck (Roberto et al., n.d.).
Protein D that are derived from the non-typeable that is called the H. influenza mostly
this has been used as the carrier of polysaccharides and this is mostly included by the GSK by
the vaccine that has been recently licensed and this is called the pneumococcal conjugate that is
multivalent. The administration of the vaccines that are multivalent conjugates is associated with
the administration of the immune interference which is like the specific carriers and helps the Tcell enhancement.
The T-cell helps in the inducement and of the epitopic suppression or the interference of
the bystander. This kind of carriers that were fond of the effects of suppression and pr...
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