High-Throughput (HTP) Technologies:
HTP screening used for assessment of compounds with therapeutic potential implies technologies, such as automated sequencing, mass spectrometry proteomics, transcriptomics, proteomics and metabolomics approaches coupled with advanced computational approaches to capturing information about an organism on a global scale to analyse and build a predictive model. The use of micro-organisms or higher cells in tissue culture genetically engineered to monitor a specific biological activity has made it possible to screen several thousands of compounds for the desired drug properties. This in turn has generated a wealth of genetic information on basic DNA, protein, and functional informational resources available worldwide. Some of these compounds will inevitably have activities that are toxic or affect animals and humans in harmful ways. Access to this knowledge would allow rapid identification of potentially dangerous agents.
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