READ THIS FIRST! Please answer the following questions thoroughly. Make sure you answer all parts of the question completely, providing all of the information that is asked for. Provide sufficient detail so that someone who is not your course instructor could understand what you are talking about. If you use any abbreviations (for example, PAMP), please define what they are. You have to demonstrate to me that you know what you are talking about; I am not going to guess. You can use course notes, and any papers that might be online with their source. There is no maximum or minimum length for your answers, but they should be complete, and as concise as possible. Please don’t include information that is not relevant to the question asked.Question 1: You have developed a strain of mice that are incapable of producing Follicular Dendritic Cells (FDCs). (This is fictional-I have no idea whether or not such a thing exists). a) What do follicular Dendritic cells do in our immune system? (Your answer needs to include specific answers to: Where are they found? What is their role in that location?b) Which immune tissues or organs would be affected by this mutation? What would they look like (e.g. what structures would be missing or altered) Be sure to consider all types of immune tissue.c. What would be the effect of this mutation on the immune system of the mice? Your answer should include whether or not the mice would be immunosuppressed, and a thorough explanation of why or why not, including what cells/functions of the immune system would be altered. Question 2: You have another mouse strain that is homozygous for HLA-A and HLA-C. It also has a homozygous inactivating mutation in the HLA-B genes. a) What are the HLA-A, B, and C genes and what do they encode? Are they part of a bigger gene locus, and, if so, what is in the rest of the locus? b) The haplotype of this mouse shows that the rest of the alleles in this locus are also homozygous. Could this result in any impairment of the mouse’s immune system? Explain your answer, making sure you explain why the HLA genes are usually polygenic and polymorphic.c) This same mouse strain carries a homozygous inactivating mutation in the gene encoding the TAP transporter. Will this have any effect on the mouse’s immune system? In your answer, describe the function of TAP, and explain (and describe) what functions are impaired because of its loss. Then explain why this would or would not have any effect on the immune system (including of course, which aspects of the immune system would be impaired).Question 3: Describe the antibody problem. In your answer, you should describe the basic structure of antibodies (secreted is fine) and how this posed a problem when scientists tried to relate structure to the necessary function of antibodies. Without going into detail about Ig genes, describe the solution to the antibody problem. Question 4) Part 1: You have been jabbed with a sharp pointy stick, and through this jab, are infected with: 1) a dsRNA virus that can infect many cell types including dendritic cells; 2) a type of intracellular bacteria that infects macrophages/dendritic cells; and 3) Streptococcus covinia (an imaginary extracellular bacteria that secrets a toxin). You had never been jabbed with these particular pathogens before, and you were not infected with a lot of any of the pathogens, so you are not sick because your innate response kicked in, and has been busy working at the site of the jab. Thus, we can move our attention to a nearby lymph node, which now contains the three pathogen types and the S. covinia toxin, as well as immune cells. a. Which of the following are required for TH cell activation? (from the list below, highlight all that apply). Then write a brief description of TH cell activation making sure that your description contains all the highlighted items.CD3 IL2Iga B7CD4 C5CD8 CD40 granzymes CD28Question 4, part 2: It is 1 month later, and unfortunately, another pointy stick jabs you with the same three pathogens. You now have plasma cells/antibodies and appropriate memory B cells, TH effector cells, as well as CTL cells, to respond to the entire infection. b. You have antibodies against the toxin and against the three pathogen types. What are the antibodies going to do to help you from getting sick?c. Some of the intracellular bacteria have succeeded in infecting some macrophages. How is your immune system going to try to remove this infection?d. What parts of the adaptive response is going to rid your body of the virus? (Don’t describe the IFN a/b, other cytokine, and NK responses, even if they would help).

Hi this is for Biology lab (EBIO 1230) , I have provided the lab notes from the lab book that can help the to answer the questions. Please answer them clearly. I'll also include the main questions so you don't have write them again. Please with in 4 or 5 hrs. if you can. I appreciate the help very much.here are the questions:- 1. Use the table below to diagram the gel. Use an X to indicate a band. Assume the wells are at the top row. In the well, indicate the sample (i.e. fly # and gene, a or b, and ladder).___________2. What size is the allele that codes for the cinnabar?__________3. What size is the allele that codes for the glossy?Table 8.1. Fill in the genotypes for all 6 flies and both genes in the following table.Fly #Cinnaber Gene Cn = Wild-Type Cn' = CinnabarGlossy Gene Gl = Wild-Type Gl' = Glossy1234564. List the potential flies that you will use to meet your objective. (Hint: your objective is listed at the bottom of the scenario subheading. Your goal is to obtain a true-breeding lineage of D. melanogaster that exhibits the cinnabar and glossy traits. For example: Can you use flies 1 and 2 from Table 8.1 and make crosses to eventually end up with your desired fly type?)5. Which of the flies listed in question 4 are pure D. melanogaster and do not represent a hybrid between D. melanogaster and D. yakuba. (Hint: Use the blast search of the sequences associated with the candidate flies to determine the species each allele came from. Be careful because heterozygous flies have more than one sequence associated with each gene so you may be checking up to four alleles for a single fly.)6. Use Punnet squares and added explanation to show the crosses needed to produce the desired true-breeding flies for the cinnabar and glossy traits.With Respect!!!Thank you!

Hi!! I have 19 Chemistry questions that I need help with! The Questions are attached! Please provide all the work for each question!