Evidence-Based Pharmacology Paper

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Topic:Hyperlipidemia

1.Synthesize relevant information, including research related to the diagnosis and treatment of the selected disorder.

2.Recognize the assumptions inherent in the current literature and identify any unstated or missing information.

3.Develop and justify various approaches to the stated problem, including nonpharmacological and pharmacological treatment.

4.Clearly articulate at least two approaches to the treatment of the condition.

5.Defend the choice of the treatment option. This must include a reflection on the availability of peer-reviewed information and your analysis of the credibility of that information.

6.Create a plan for follow-up and referral if needed.

Submit your answers in a Microsoft Word document of 10–15 pages. Include peer-reviewed references in APA format. Be sure to review the directions and grading criteria to assure that you will cover the content well.

Grading Criteria

Described the pathophysiology of the disease process in depth. Included a discussion of the implications of the age continuum for this disease.

Discussed the genomic issues inherent in the disease process, including what is known and what is not known.

Provided a review of the literature on the basics of the disease and its treatment.

Described your approach to collecting this needed information. Included what keywords you used in a literature search, which databases were utilized, and any electronic clinical tools.

Identified and utilized at least one published clinical guideline related to the disease process.

Described the approach to the treatment of the specific disease, including the various possible approaches.

Defended the final selection of the approach for the disease process.

Discussed follow-up treatment, along with any referrals.

Utilized a minimum of five peer-reviewed articles published within the last seven years.

Provided references in APA style.

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Explanation & Answer

Attached.

Running head: HYPERLIPIDEMIA

1

Hyperlipidemia
Name
Institution

HYPERLIPIDEMIA

2
Introduction

The healthcare environment has been shifting significantly with emergence many lifestyle
illnesses, which have been detrimental to public health. Hyperlipidemia is a medical term, which
highlights the abnormally high level of lipids in the blood. It is a common problem in the current
healthcare. Hyperlipidemia covers several disorders that result from excessive fats in the human
body. The two major types of lipids in blood include cholesterol and triglycerides. The
triglycerides are formed when human body excess calories. Excess calories that are highlighted in
this case come directly from the foods consumed. Cholesterol is fats which are produced in the
liver although there is need to ensure that they are maintained within desired levels because they
are also highly influenced by the type of foods consumed such as red meat. Hyperlipidemia is
mainly developed because of unhealthy lifestyles. This research paper provides an in-depth
analysis of hyperlipidemia condition based on pathophysiology and treatment of this condition.
Pathophysiology
Hyperlipidemia involves a higher level of lipids in the blood, and it is currently one of the
most observed conditions linked to the cardiovascular system. The larger deposition of fats in the
blood is very dangerous. The pathophysiology of the hyperlipidemia can be classified into two
broader categories, which include primary and secondary hyperlipidemia. Genetic factors are
responsible for the development of the primary hyperlipidemia while metabolic disorders case
secondary hyperlipidemia.
Genetic hyperlipidemia is categorized into various disorders including familial
hypercholesterolemia, familial hypertriglyceridemia, and familial combined hyperlipidemia. The
familial hypercholesterolemia is a genetic disorder, which develops because of high levels of low-

HYPERLIPIDEMIA

3

density lipoprotein in the blood. Familial hypertriglyceridemia is another genetic condition which
is a highly prevailing condition that develops as a result of mass production of very low-density
lipoprotein while the Familial dysbetalipoproteinemia is a genetic disorder that forms as a result
of increased production of very low-density lipoprotein and decreased high-density lipoprotein.
There is the need for stable integration of both the high density and low-density lipoproteins in
creating a steady development process with high-level blood flow (Nordestgaard et al., 2013). The
genetic consideration, in this case, focuses on a mutated gene that is inherited from a parent, which
cause malfunction of the low-density lipoprotein receptor. Thus, as a result, the Low-density
lipoproteins accrues to significantly higher amounts in the blood which is a risk to any individual
who has a higher level of focus. The genetic elements, in this case, are more severe and requires
significant engagement to limit the overall level of engagement. The treatment measures of
genetically developed hyperlipidemia vary (Navar-Boggan et al., 2015).
Some factors, which include high alcohol consumption, high drug usage and renal failure
and poor diet, causes secondary hyperlipidemia. Understanding causes of secondary
hyperlipidemia require significant focus on important risk factors. Premature atherosclerosis is a
significant cause of the reduced life patients suffering from diabetes mellitus. Complications that
occur in this case include plaque rupture, thrombotic occlusion. Hyperlipidemia is most common
in this case in patients who have diabetes because there is reduced underlying elements, which can
create a greater understanding of what needs to be undertaken. Hypothyroidism is another risk
condition which creates a better environment where hyperglycemia condition can develop, and
thus untreated levels of hypothyroidism are detrimental to human body since it causes
abnormalities in plasma lipids and lipoprotein levels in a patient (Nordestgaard et al., 2013).

HYPERLIPIDEMIA

4

Hyperlipidemia is also common among patients with renal failure. During hemodialysis
procedures, the TG levels usually increase and in the process cause hyper triglyceride. It is also
linked to reduced lipoprotein lipase activity in the human body. Obesity is a critical condition
which is associated with excessive intake of calories with limited loss of them whereby in the
process create a very difficult environment because a lot of unused energy which is stored in the
body. Individuals suffering from obesity has a high chance of drop syndrome. Obesity in this case
together with individual lifestyle and genetic factors interact to create the drop syndrome. Alcohol
presents another significant cause of hyperlipidemia where heavy drinkers are likely to develop
this condition due to high-calorie content, especially in beer and wine. Alcohol, therefore, has an
injurious effect on lipid profile since the TG ...


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