Genetic Literacy across the Lifespan

Anonymous
timer Asked: Dec 15th, 2017
account_balance_wallet $15

Question description

see attachments and follow instructions closely for the exercised, it has complete explanation of the work needed

Module 2 Genetic Mutations Exercise Instructions: Below you are given an imaginary wildtype sense strand (coding strand) of DNA and the corresponding mature mRNA sequence with its corresponding protein sequence. Five mutant DNA sense strands are presented. For each mutant DNA strand (mutant 2-5), write the mRNA strand, the protein sequence, and an explanation of the type(s) of mutation represented, including the impact on protein synthesis. I have completed the first mutant as an example. I will post the answers after the assignment has been submitted. This is a required homework activity worth 5 points. Wildtype sense strand sequence: ATG-TCA-CCC-GCG-CAG-GAA-GGA (Upper case letters denote coding sequence of the DNA) Mature mRNA sequence: AUG-UCA-CCC-GCG-CAG-GAA-GGA Protein sequence: methionine-serine-proline-alanine-glutamine-glutamic acid-glycine Mutant 1: ATG-TGA-CCC-GCG-CAG-GAA-GGA mRNA: AUG-UGA-CCC-GCG-CAG-GAA-GGA Protein: methionine-stop Mutation: The fifth base is changed from a C to a G. This is a point mutation (and a base substitution). The mutation causes a nonsense mutation because a codon for serine is replaced by a stop codon, resulting in a truncated protein. Mutant 2: ATG-TCA-ACC-GCG-CAG-GAA-GGA mRNA: Protein: Mutation: Mutant 3: mRNA: Protein: Mutation: ATG-CAT-TCA-CCC-GCG-CAG-GAA-GGA Mutant 4: ATG-TCA-CCC-GCG-CAG-GAA-GGC mRNA: Protein: Mutation: Mutant 5: ATG-T_A-CCC-GCG-CAG-GAA-GGA mRNA: Protein: Mutaton: Module 3: Transcription and Translation Exercise Questions: Below is an imaginary sequence of DNA. This sequence represents the sense strand of the double helix. It contains both exons and introns. The sequences in upper case are exons, and sequences in lower case are introns. a). write the complementary sequence of the template DNA strand and label the 5' and 3' ends of this sequence. b). write the RNA primary transcript sequence and label the 5' and 3' ends. c). write the mature mRNA sequence and label the 5' and 3' ends and indicate where the cap and poly A tail are located. d). 1) break the mature mRNA into codons 2) write out the anticodon sequence for each codon (the anticodon sequence is part of a tRNA molecule) 3) name the amnio acid that each codon specifies. Sense strand sequence: 5'agccaatgatgATGGTGCACCTGgttagacctcagtacatACTCCTgtcctcactcctatAAGTCTTAG3'

Tutor Answer

DENIQUE
School: UT Austin

Attached.

INSERT SURNAME HERE: 1

Genetic Mutations
Institutional Affiliation
Date
Module 2
Genetic Mutations Exercise

Mutant 1: ATG-TGA-CCC-GCG-CAG-GAA-GGA
mRNA:

AUG-UGA-CCC-GCG-CAG-GAA-GGA

Protein: Methionine-stop
Mutation: The fifth base is changed from a C to a G. This is a point mutation (and a base
substitution). The mutation causes a nonsense mutation because a codon for serine is replaced
by a stop codon, resulting in a truncated protein.

Mutant 2: ATG-TCA-ACC-GCG-CAG-GAA-GGA
mRNA: AUG-UCA-ACC-GCG-CAG-GAA-GGA
Protein: Methionine

INSERT SURNAME HERE: 2
Mutation: The codon AAC becomes the codon ACC and does not change because the genetic
code is degenerate, the codon will still code fo...

flag Report DMCA
Review

Anonymous
Totally impressed with results!! :-)

Similar Questions
Hot Questions
Related Tags

Brown University





1271 Tutors

California Institute of Technology




2131 Tutors

Carnegie Mellon University




982 Tutors

Columbia University





1256 Tutors

Dartmouth University





2113 Tutors

Emory University





2279 Tutors

Harvard University





599 Tutors

Massachusetts Institute of Technology



2319 Tutors

New York University





1645 Tutors

Notre Dam University





1911 Tutors

Oklahoma University





2122 Tutors

Pennsylvania State University





932 Tutors

Princeton University





1211 Tutors

Stanford University





983 Tutors

University of California





1282 Tutors

Oxford University





123 Tutors

Yale University





2325 Tutors