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Grrnpuuu04

Health Medical

Nova Southeastern University

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I'm working on a nursing question and need an explanation and answer to help me learn.

You have a 46 y/o African American female with diagnosis of myocardial infarction, hyperlipidemia and hypertension.  She was started on simvastatin 40 mg for her hyperlipidemia and metoprolol tartrate 25 mg twice daily for cardiac protection and hypertension.  She remains hypertensive at 152/88.  Which medication class would you consider for her hypertension? 

  • List the following for each of the 6 major antihypertensive drug classes (ACE inhibitor, Calcium Channel Blocker, Beta Blocker, ARB, loop diuretic, and thiazide) 
    • Drug Classification
    • Name of one drug in the classification
    • Mechanism of Action
    • Side effects 
    • Contraindications
    • Drug Interaction

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Treatment of Hypertension
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Treatment of Hypertension
ACE inhibitors are drugs in the angiotensin-converting enzyme classification (Herman et
al., 2022). A drug in the ACE inhibitors classification is Benazepril (Dahal & Gupta, 2022). The
mechanism of the drug’s action is the conversion of angiotensin I into angiotensin II. The side
effects are dry cough, fatigue, dizziness due to low blood pressure, headaches, hyperkalemia, and
loss of taste. The contradictions are the history of angioneurotic oedema, renal artery stenosis,
pregnancy, and ACE inhibitor-related allergies (Montinaro & Cicardi, 2020). The drug interaction
occurs with captopril-digoxin and heart failure patients. Another drug interaction occurs with
captopril-probenecid resulting in a reduction of clearing captopril.
Calcium Channel Blocker belongs to the drug classification of therapeutic class. One
example is benzothiazepines or diltiazem. The mechanism of action involves preventing calcium
ions’ entry into the cardiac cells and arteries (Aljehani et al., 2022). The side effects are
constipation, dizziness, headache, fatigue, increased heart rate, flushing, nausea, and rash (Zhu et
al., 2021). The contradictions are hypersensitivity to calcium channel blockers, severe
hypotension, pulmonary congestion, ...

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