Biochemistry 2

User Generated

snwre25

Health Medical

biochem

king faisal univarsety

Description

The assignment must be at least 4 pages (excluding the title page and reference page).

  • Font: Times New Roman
  • Font size: 12
  • Line spacing: Single
  • Margins: Normal (default settings in Word)
  • Copy-pasting more than 20% of the content is not allowed.
  • Assignments written using artificial intelligence will not be accepted.
  • Unformatted Attachment Preview

    Assignment Writing Guidelines Dr. Aminur Rahman ASSIGNMENT Biochemistry-2, 2024-2025 (Max Marks: 5) Important information 1. This is NOT a group assignment. Every student must prepare his/her topic individually. 2. Handwritten must consist of at least 5 pages, except the title page and reference page 3. MS Word assignments of at least 4 pages (Times New Roman, normal margin, 12 fonts, single line space), except for the title and reference pages. 4. Copy & pasted (more than 20% plagiarism detected) assignments will not be graded. 5. Assignments written using AI (artificial intelligence) will not be graded. 6. Assignments must be submitted by 6th April 2025 Cover page Course: Biochemistry-2 Assignment topic: Name of the student: ID: Instructor: Dr. Aminur Rahman Understand the Assignment Requirements & Follow the rubric Make sure you understand the topic to write, questions and sub questions. Digestion and absorption of carbohydrates 1. List all steps of digestion and absorption 2. Describe the enzyme involved in the process 3. Describe any diseases related to digestion or absorption Plan and Structure Your Writing Break down the assignment into sections You may use different color for different title and subtitle Use credible sources & Appropriate Referencing Gather information from reliable and reputable academic sources such as peer-reviewed journals, textbooks, or research papers. Ensure all sources are properly cited. Do not use Wikipedia for the reference Examples in the next slides Highlight diseases related to the glycolysis pathway Highlighting diseases related to the glycolysis pathway provides insight into the crucial role in human health. Here are some diseases associated with abnormalities in glycolysis. Glycogen storage diseases (GSDs): GSDs are a group of metabolic disorders characterized by defects in enzymes involved in glycogen metabolism, including glycolysis. GSD Type 0, caused by mutations in the G6PC gene encoding glucose-6phosphatase, affects the final step of glycogenolysis and can lead to hypoglycemia and hepatomegaly [1]. Cancer: Dysregulated glycolysis is a hallmark of cancer cells, known as the Warburg effect. Cancer cells often exhibit increased glucose uptake and glycolytic flux, even in the presence of oxygen (aerobic glycolysis), to support their rapid proliferation and survival. This metabolic rewiring contributes to tumor growth, metastasis, and resistance to therapy [2]. Diabetes Mellitus: Both type 1 and type 2 diabetes involve dysregulation of glucose metabolism. In type 1 diabetes, autoimmune destruction of pancreatic β-cells leads to insulin deficiency, impairing glucose uptake and utilization. In type 2 diabetes, insulin resistance and impaired insulin secretion disrupt glucose homeostasis, leading to hyperglycemia. Dysfunctional glycolysis contributes to metabolic abnormalities observed in diabetic patients [3]. Cardiovascular diseases: Altered glycolytic metabolism is implicated in various cardiovascular disorders, including heart failure, ischemic heart disease, and hypertrophic cardiomyopathy. Dysfunctional glycolysis affects energy production and myocardial function, contributing to the pathogenesis of these conditions [4]. References: 1. Bali DS, Chen YT, Austin S. (2009). Glycogen Storage Disease Type I. In: Adam MP, Ardinger HH, Pagon RA, et al., editors. GeneReviews: University of Washington, Seattle; 1993-2022. 2. Liberti MV, Locasale JW. (2016). The Warburg Effect: How Does it Benefit Cancer Cells? Trends Biochem Sci. 2016 Aug;41(3):211-8. 3. Newsholme P, Keane D, Welters HJ, Morgan NG. (2007). Life and death decisions of the pancreatic β-cell: the role of fatty acids. Clin Sci (Lond). 2007 Nov;112(3):27-42. 4. Lopaschuk GD, Ussher JR, Folmes CD, Jaswal JS, Stanley WC. (2010). Myocardial fatty acid metabolism in health and disease. Physiol Rev. 2010 Jan;90(1):207-58. Write Clearly and Concisely Provide a clear statement. Use paragraphs to organize your thoughts. Different paragraphs for different answer. Use proper formatting: Follow margins, font size, headings, and spacing. Please do not write like the following Think that someone will read your writing and evaluate it Please do not write like the following Think that someone will read your writing and evaluate it Review and Proofread Double-check that you have addressed all the topics and your hand writing is readable. Submit on Time Avoid last-minute submissions: Allow yourself enough time to submit the assignment. Assignments must be submitted on or before 6th April, 2025
    Purchase answer to see full attachment
    User generated content is uploaded by users for the purposes of learning and should be used following Studypool's honor code & terms of service.

    Explanation & Answer

    Attached.

    1

    Digestion and Absorption of Carbohydrates
    Student name
    Institution name
    Course
    Instructors name
    Date

    2

    Introduction
    The body uses carbohydrates as its primary energy source, making them a vital nutrient.
    Although carbohydrates can be found in a wide variety of meals, including fruits, vegetables,
    grains, and dairy products, the body needs them for energy if they cannot be broken down and
    absorbed. This process involves several steps from the mouth to the small intestine, where simple
    sugars are produced from carbs and absorbed into the blood. Because certain enzymes and
    transport mechanisms are active, carbohydrates are efficiently digested and absorbed. Disruption
    of these mechanisms can lead to various digestive problems. The steps involved in the digestion
    and absorption of carbohydrates will be thoroughly described in this essay, along with the
    identification of the enzymes that aid in these processes and the illnesses that result from
    inadequate digestion or absorption of carbohydrates.
    The Process of Carbohydrate Digestion
    Food enters the mouth during the initial digestion of carbohydrates since there are no
    dietary constraints. Chewing breaks food into tiny bits, and saliva, which contains the enzyme
    salivary amylase, mixes with the meal. This enzyme starts the breakdown of complex
    carbohydrates called starches, which are made up of long-chain glycoside molecules (Sensoy,
    2021). Maltose and dextrins, which are smaller chains of glucose, are the sugar molecules that
    are produced when salivary amylase hydrolyzes starches. Even if the food is only in the mouth
    for a brief period, the initial enzymatic activity is essential for initiating the digestive process and
    releasing the mechanical pressure on the subsequent gastrointestinal organs.
    After being swallowed, the food passes down the esophagus and into the stomach, where
    the breakdown of carbohydrates is momentarily stopped. The stomach's acidic environment
    deactivates salivary amylase, which is necessary for the digestion of proteins (Sensoy, 2021).
    Although the stomach does not play a significant role in the digestion of carbohydrates, the
    mechanical churning of the stomach walls aids in the mixing and churning of food with gastric
    secretions. After going through this process, the food becomes chyme, a semi-liquid substance
    that is progressively released into the duodenum, the first segment of the small intestine.
    Only in the small intestine, where the majority of nutritional breakdown and absorption
    occurs, does carbohydrate digestion typically continue (Sensoy, 2021). At this point, the
    pancreas secretes the pancreatic amylase into the duodenum. This potent enzyme will continue to
    break down the remaining complicated carbohydrates into disaccharides like maltose after the
    neurons have finished breaking them down (that is, except for the most basic ones).
    The brush border enzymes, which are located across the intestinal villi, typically come
    into contact with the digested material after it has passed through the small intestine. These
    enzymes—lactase, sucrase, and maltase—complete digestion at the conclusion of the digestive
    process and split disaccharides into monosaccharides like glucose, fructose, and galactose
    (Sensoy, 2021). They are sufficiently tiny to pass past the intestinal tract and into the
    bloodstream, where they can be delivered to and utilized by cells for energy production. At this
    stage, the digestion of carbohydrates is finished, and the proper function of digestive enzymes
    and the presence of healthy intestinal structures are crucial to this process.
    Final Breakdown and Absorption
    The small intestine's microvilli are home to brush border enzymes, which are necessary
    for further breaking down disaccharides into monosaccharides. Lactase, sucrase, and maltase are
    among the enzymes (Montoro-Huguet et al., 2021). Maltose is broken down into two glucose
    molecules by maltase. The enzyme sucrase breaks down sucrose into one glucose molecule and

    3

    one fructose molecule (Montoro-Huguet et al., 2021). Lactase converts lactose to galactose and
    glucose. Lastly, the absorbable forms of carbohydrates are these monosaccharides.
    The carbohydrates must pass through the i...

    Similar Content

    Related Tags