Pharmacogenomics in Primary Care

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Question Description

Pharmacogenomics in Primary Care

Explain one of the following statements in your own words. Give an example of implications for you as the prescribing primary care provider.

  1. Carbamazepine has a black box warning recommending testing for the HLA-B*1502 allele in patients with Asian ancestry prior to starting therapy.
  2. Testing for CYP2D6 variants prior to starting tamoxifen for breast cancer.
  3. A genetic variation in how the metabolite of the cancer drug irinotecan SN-38 is inactivated by the body.

Tutor Answer

Juniper
School: Carnegie Mellon University

Hello buddy, kindly find your paper attached below. Let me know what you think. Thank you

Running Head: PHARMACOGENOMICS IN PRIMARY CARE

Pharmacogenomics in Primary Care
Student Name
Institutional Affiliation

1

PHARMACOGENOMICS IN PRIMARY CARE

2

3. A genetic variation in how the metabolite of the cancer drug irinotecan SN-38 is
inactivated by the body.
In the body, Irinotecan is changed into an active metabolite called SN-38. When this
happens, the drug becomes detoxified and inactivated by a UDP-glucuronosyltransferase , which
a (UGT) enzyme formed by a gene called UGT1A1 gene. According to Chen et al. (2015), the
UGT enzymes main responsibility is in the process of transforming lipophilic metabolites to
become metabolites that are soluble in water. These water-soluble metabolites are then excreted
out of the body. Due to the toxicity of irinotecan during cancer treatment, cancer patients’
genetic variants used in reducing the activity of the UGT enzyme are increased. For instance, it
brings about the presence of UGT1A1*28. Consequentl...

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