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lnyzne01

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Power Point Assignment (approximately 15 slides): - Protease Inhibitors and Integrase Strand-Transfer Inhibitors

  • Synopsis about the class of antiviral assigned.
  • Mechanism of action
  • Resistance
  • Pharmacokinetics

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Explanation & Answer

Attached.

Protease Inhibitors And Integrase
Strand-transfer Inhibitors
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Drug Class
✓ Drug class is a group of drugs that share common properties.
✓ Approved ARV drugs are divided into 6 classes:
➢ Integrase strand transfer inhibitors.
➢ CCR5 antagonists.
➢ Protein Inhibitors.
➢ Non-nucleoside reverse transcriptase inhibitors.
➢ Nucleoside reverse transcriptase inhibitors.

Integrase Strand-Transfer Inhibitors
✓ Also called Integrase Inhibitor.
✓ Is an Antiretroviral drug class.
✓ Block Integrase.
✓ HIV uses Integrase to integrate its viral DNA into the DNA of the

host CD4 cell.
✓ Blocking Integrase prevents HIV from replicating.

Integrase
✓ Enzyme found in HIV .
✓ HIV uses Integrase to its viral DNA into the
DNA of host CD4 cell.
✓ Integration is blocked by Integrase Stra...

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