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Tumor Angiogenesis Chapter 17 Summary

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Tumor Angiogenesis Summary 1
Tumor Angiogenesis: Chapter 17 Summary
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Tumor Angiogenesis: Chapter 17 Summary
The author in the textbook “The Molecular Basis of Cancer” points out that all tumors need a
vascular system to grow and develop. Tumor angiogenesis refers to a process through which
healthy cells are stimulated by tumors to produce signaling molecules of angiogenesis. The
process by which new blood vessels are created from pre-existing vessels is called Angiogenesis.
This process occurs during healing wound. Also, it happens during growth as well as
development. Notably, tumors rely on Angiogenesis for metastasizing and proliferation. The
chapter shade light on the characteristics of malignant and normal vascular tissue development.
Also, it focuses on clinical during evaluations and the ongoing development of anti-angiogenic
therapies.
Vascular Development
Normal Vasculature
Vasculogenesis refers to blood vessel formation, which takes place embryonic organogenesis.
During this process, angioblasts undergo differentiation into vascular endothelial cells (ECs).
The de novo on the yolk is aggregated by the cells to form a primitive vascular network. The
author maintains that Angiogenesis takes place in two different forms. These fashions entail
intussusceptions or sprouting.
Whenever the receptors on endothelial cells are activated by angiogenic growth factors
Sprouting Angiogenesis is said to have taken place. Once the ECs are activated, they start to
debase the basement membrane. Hence, it loosens its connections to its supportive cells. This
causes the cells to start proliferating and change shape. Generally, Sprouting Angiogenesis
occurs in parallel with Intussusception Angiogenesis. On the other extreme, Intussusception

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1 Tumor Angiogenesis Summary Tumor Angiogenesis: Chapter 17 Summary Student’s Name Institutional Affiliation 2 Tumor Angiogenesis Summary Tumor Angiogenesis: Chapter 17 Summary The author in the textbook “The Molecular Basis of Cancer” points out that all tumors need a vascular system to grow and develop. Tumor angiogenesis refers to a process through which healthy cells are stimulated by tumors to produce signaling molecules of angiogenesis. The process by which new blood vessels are created from pre-existing vessels is called Angiogenesis. This process occurs during healing wound. Also, it happens during growth as well as development. Notably, tumors rely on Angiogenesis for metastasizing and proliferation. The chapter shade light on the characteristics of malignant and normal vascular tissue development. Also, it focuses on clinical during evaluations and the ongoing development of anti-angiogenic therapies. Vascular Development Normal Vasculature Vasculogenesis refers to blood vessel formation, which takes place embryonic organogenesis. During this process, angioblasts undergo differentiation into vascular endothelial cells (ECs). The de novo on the yolk is aggregated by the cells to form a primitive vascular network. The author maintains that Angiogenesis takes place in two different forms. These fashions entail intussusceptions or sprouting. Whenever the receptors on endothelial cells are activated by angiogenic growth factors Sprouting Angiogenesis is said ...
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