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Multiple Sclerosis and Amyotrophic Lateral Sclerosis Discussion

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Running head: CLINICAL MANIFESTATIONS CLINICAL PROGNOSIS ,
AND PATHOPHYSIOLOGY 1
Multiple Sclerosis and Amyotrophic Lateral Sclerosis
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CLINICAL MANIFESTATIONS CLINICAL PROGNOSIS, AND PATHOPHYSIOLOGY 2
Multiple sclerosis (MS) is a disease that disables the CNS (Central Nervous System) and
the brain. It disrupts information flow from the brain to other body parts and the brain (Frederick,
& Cameron, 2018). On the other hand, amyotrophic lateral sclerosis (ALS) is a neuron disease
that causing dysfunction of the muscles controlling voluntary movement (Beers & Appel, 2019).
Both multiple sclerosis and amyotrophic lateral sclerosis affect the spinal cord and brain, and the
ability to move (muscles).
In multiple sclerosis, myelin sheaths in the spinal cord and the brain are attacked and
damaged hence signal transfer from the brain to other body parts are “short-circuited”. This is a
neurodegenerative disease which targets the CNS, facilitated by autoreactive lymphocytes that
cross the BBB (blood-brain barrier) entering the CNS and causing inflammations (Frederick, &
Cameron, 2018). In advanced stages a patient suffers from swallowing problems, blood clots
caused by immobility, mental confusion, increased pain levels, and breathing problems. In
contrast, Amyotrophic lateral sclerosis damages the actual nerve cells in the spinal cord and the
brain. These affect the motor neurons responsible for the voluntary movement of muscles losing
control of motor function.in the severe stages, a patient may be paralyzed and mobility is
extremely compromised. A patient can also have respiratory difficulties as well as for MS.
Multiple sclerosis is manifested through symptoms that are related to the Central
Nervous System. Most common clinical manifestations of MS are; paresthesias that are sensory
loss majorly on the early complains, cramping of muscles, bladder dysfunction, depression
which is common, pain in muscles, eye symptoms like diplopia that is double vision, and optic
neuritis(inflammation of eye’s optical nerve). In addition, a patient with multiple sclerosis may

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Running head: CLINICAL MANIFESTATIONS CLINICAL PROGNOSIS AND PATHOPHYSIOLOGY Multiple Sclerosis and Amyotrophic Lateral Sclerosis Name University Date , 1 CLINICAL MANIFESTATIONS CLINICAL PROGNOSIS, AND PATHOPHYSIOLOGY 2 Multiple sclerosis (MS) is a disease that disables the CNS (Central Nervous System) and the brain. It disrupts information flow from the brain to other body parts and the brain (Frederick, & Cameron, 2018). On the other hand, amyotrophic lateral sclerosis (ALS) is a neuron disease that causing dysfunction of the muscles controlling voluntary movement (Beers & Appel, 2019). Both multiple sclerosis and amyotrophic lateral sclerosis affect the spinal cord and brain, and the ability to move (muscles). In multiple sclerosis, myelin sheaths in the spinal cord and the brain are attacked and damaged hence signal transfer from the brain to other body parts are “short-circuited”. This is a neurodegenerative disease which targets the CNS, facilitated by autoreactive lymphocytes that cross the BBB (blood-brain barrier) entering the CNS and causing inflammations (Frederick, & Cameron, 2018). In advanced stages a patient suffers from swallowing problems, blood clots ca ...
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