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Duchenne Muscular Dystrophy

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Duchenne muscular dystrophy (DMD)

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Duchenne muscular dystrophy (DMD)

This is a hereditary muscle disease that mostly affects the male gender; however, in girls, it

mildly affects them, or they can be carriers. The disorder starts to manifest itself at the age of

four, and from there, it progresses rapidly. The main areas affected include the thighs, pelvis, and

arms. The weaknesses or degeneration in the muscles are attributed to the inhibition of a protein

called dystrophin. The essence of the dystrophin is to keep the muscle cells intact. The

dystrophin binds the cytoskeleton of the muscle fiber to the surrounding extracellular matrix

(Laviola & Aliverti, 2018). This type of disorder affects the physical appearance of the muscle,

alters the contraction of the muscle, and affects certain types of muscle fibers.

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1 Duchenne muscular dystrophy (DMD) Student’s name Institutional affiliation Course name Instructor’s name Assignment due date 2 Duchenne muscular dystrophy (DMD) This is a hereditary muscle disease that mostly affects the male gender; however, in girls, it mildly affects them, or they can be carriers. The disorder starts to manifest itself at the age of four, and from there, it progresses rapidly. The main areas affected include the thighs, pelvis, and arms. The weaknesses or degeneration in the muscles are attributed to the inhibition of a protein called dystrophin. The essence of the dystrophin is to keep the muscle cells intact. The dystrophin binds the cytoskeleton of the muscle fiber to the surrounding extracellular matrix (Laviola & Aliverti, 2018). This type of disorder affects the physical appearance of the muscle, alters the contraction of the muscle, and affects certain types of muscle fibers. 3 1. Physical appearance Dystrophin is a long cohesive (binding) protein between the sarcolemma and the outermost layer of the myofilaments. It is found on the inside of every muscle fiber’s plasma membrane (sarcolemma). The protein links with two other consecutive proteins which are also attached to the fibrous endomysium of the muscle fiber (Giliberto et al., 2014). The absence of the dystrophin will make the sarcomere appear fragile and the myosin filaments will be loosely attached to the inside of the muscle fiber. 2. Effect of the disease on muscle contracti ...
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Tags: plasma membrane Muscle Contraction muscle cells Duchenne muscular dystrophy weaknesses or degeneration

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