Letter Of Intent On Alcohol Poisoning

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Biochemistry

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Ryerson University

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BCH361

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Running head: LETTER OF INTENT 1

Letter of Intent on Alcohol Poisoning

Name:

Institution:

Course Code

LETTER OF INTENT 2

Background Section

Methanol is also commonly referred to as wood alcohol. It can also be used as an organic

solvent since it is very toxic. Methanol can cause neuronal sequelae, metabolic acidosis and

sometimes it can result to even death. The components of methanol are mainly commercially

available industrial solvents together with poorly made alcoholic beverages. Methanol toxicity is

a common problem to all parts of the world especially to developing countries. Sophisticated

technique in methanol imaging has made it possible to detect intoxication of methanol. In

addition to that it is easier to detect neurological disorders which are more frequent. This is only

possible because earlier recognition of methanol toxicity will result in earlier advances of the

supportive care. Better management of acid base disturbance and hemodialysis is vital in the

therapeutic improvements. (1) Methanol intoxication can result in several changes in the ECG

for example with sinus tachycardia and with T waves changes which are non specific. According

to a study which was done by Jef etc sinus tachycardia and changes in T waves were more prone

in those individuals with severe acidosis. In a retrospective chart of nine patients, it was evident

that those individual who had a higher concentration of plasma methanol and lower pH levels

were mainly associated with multiple changes in their ECG. Changes in ECG on their admission

included, sinus tachycardia, QTc prolongation, PR prolongation and non specific changes in T

waves. A type one brugada ECG pattern was developed in one of the patients.

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How alcohol dehydrogenase interacts with the substrate methanol via active site

What is the functional part of this amino acid

The functional part of the amine group of the arginine amino acid is the active site.

What other active site atom(s) are in closest contact with this residue and what is this residue’s

possible role(s)?

The negatively charged oxygen of the phosphate group is in close contact with the positively

charged residue. This interaction keeps the phosphate in the proper conformation.

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Running head: LETTER OF INTENT 1 Letter of Intent on Alcohol Poisoning Name: Institution: Course Code LETTER OF INTENT 2 Background Section Methanol is also commonly referred to as wood alcohol. It can also be used as an organic solvent since it is very toxic. Methanol can cause neuronal sequelae, metabolic acidosis and sometimes it can result to even death. The components of methanol are mainly commercially available industrial solvents together with poorly made alcoholic beverages. Methanol toxicity is a common problem to all parts of the world especially to developing countries. Sophisticated technique in methanol imaging has made it possible to detect intoxication of methanol. In addition to that it is easier to detect neurological disorders which are more frequent. This is only possible because earlier recognition of methanol toxicity will result in earlier advances of the supportive care. Better management of acid base disturbance and hemodialysis is vital in the therapeutic improvements. (1) Methanol intoxication can result in several changes in the ECG for example with sinus tachycardia and with T waves changes which are non specific. According to a study which was done by Jef etc sinus tachycardia and changes in T waves were more prone in those individuals with severe acidosis. In a retrospective chart of nine patients, it was evident that those individual who had a higher concentration of plasma methanol and lower pH levels were mainly associated with multiple ...
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