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Biochemistry Questions Chapter 12

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Subject
Biochemistry
School
University of Arizona
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Q12.1
Although 3 H
+
ions are required by ATP synthase to convert ADP to ATP, one H
+
ion is required
to import one P
i
ion into the matrix essential for the conversion to proceed.
Mitochondrial Shuttle Systems
Q12.2
In the mitochondria, oxidation of one mole of NADH translocates 10 moles of H
+
and uses 4
moles of H
+
to synthesize 4 moles of ATP, hence a net of 10/4 = 2.5 moles. In the muscle cell
cytosol, 4 less moles of H
+
ions are translocated while 4 moles are used to synthesize 4 moles of
ATP, hence a net of 6/4 = 1.5 moles.
Regulation of Oxidative Phosphorylation
Q12.3
The LHON phenotype is mitochondrial disease which is inherited directly from the mother
because the sperm does donate mitochondria. Sickle cell anemia is autosomal recessive disease
inherited from both parents.
Follow-up Question
Q12.3 What is the key difference between the transport system in liver cells and in muscle cells
mitochondria relating to the oxidation of NADH?

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Q12.1 Although 3 H+ ions are required by ATP synthase to convert ADP to ATP, one H+ ion is required to import one Pi ion into the matrix essential for the conversion to proceed. Mitochondrial Shuttle Systems Q12.2 In the mitochondria, oxidation of one mole of NADH translocates 10 moles of H+ and use ...
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