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Pharmacology notes

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Lipid lowering drugs Cholesterol: What is 1 it? Cholesterol is a fatty steroid made primarily in the liver of most animals and humans. It is an integral component in the synthesis of hormones, can also be found in cell walls of animals and humans. Isolated cholesterol is a white, flaky solid that is insoluble in aqueous environments. Cholesterol H O Two types of transportation for cholesterol In order to transport the steroid through blood, cholesterol is attached to a set of proteins called lipoproteins. There are two types of lipoproteins: high density and low density lipoproteins. HDL: High-density lipoproteins – collect cholesterol particles as they travel through blood vessels and deposits them in the liver where they are transferred to bile acids and disposed off. LDL: Low-density lipoproteins –deposits on the walls of blood vessels, and over time, builds up into cholesterol plaque and blocks blood vessels, especially arteries that feed blood to the heart. The liver manufactures, secretes and removes LDL cholesterol from the body. To remove LDL cholesterol from the blood, there are special LDL receptors on the surface of liver cells. 1. 2. LDL receptors remove LDL cholesterol particles from the blood and transport them inside the liver. A high number of active LDL receptors on the liver surfaces is necessary for the rapid removal of LDL cholesterol from the blood and low blood LDL cholesterol levels. A deficiency of LDL receptors is associated with high L ...
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