Work from the Brown and Goldstein lab provided insights into cholesterol homeostasis that were used to develop several of the LDL cholesterol-lowering therapies, including statins that remain in use today. However, in some patients, statins were not as effective as expected, suggestive of additional mechanisms regulating the LDL receptor. Investigate other LDL cholesterol-lowering therapies (other than PCSK-9 inhibitors), select 1, and compare and contrast the mechanisms of action between the class of drug you select and statins. Include side effects for both types of drugs and information on their efficacy.APA styleWebsite for the Brown and Goldstein lab article : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC42711...

Activity 3 Continuum of Care  Explain how the concept continuum of care is used in case management and within your organization.  What new services/programs are your organization currently evaluating or performing that are assisting patients to reach their health goals?  How do these services/programs impact the bottom line of the organization?  Quality indicators, such as accessibility, appropriateness, continuity, effectiveness, efficacy, efficiency, timeliness, patient perspective issues, and safety, can influence quality of care. Choose one indicator and discuss its influence on care inventory environments, including local, state, national, and global. Discuss the practice of linking hospital reimbursement to performance outcomes. Reading & Resources Chapter 2 pages 44-47 in Fundamentals of Case Management Practice De Regge, M., Pourcq, K. D., Meijboom, B., Trybou, J., Mortier, E., & Eeckloo, K. (2017). The role of hospitals in bridging the care continuum: A systematic review of coordination of care and follow-up for adults with chronic conditions. BMC Health Services Research, 17 Davis, M. M., Devoe, M., Kansagara, D., Nicolaidis, C., & Englander, H. (2012). "Did I do as best as the system would let me?" healthcare professional views on hospital to home care transitions. Journal of General Internal Medicine, 27(12), 1649-56. Asgar, A. H., Ravaghi, H., Kringos, D. S., Ogbu, U. C., Fischer, C., Azami, S. R., & Klazinga, N. S. (2014). Using quality measures for quality improvement: The perspective of hospital staff. PLoS One, 9(1) Buerhaus, P. I., DesRoches, C., Applebaum, S., Hess, R., Norman, L. D., & Donelan, K. (2012). Are nurses ready for health care reform? A decade of survey research. Nursing Economics, 30(6), 318-29, quiz 330. Elwood, T. W., DrP.H. (2013). Health reform in the context of entelechy. Journal of Allied Health, 42(3), 127-34.  Feemster, L. C., & Au, D. H. (2014). Penalizing hospitals for chronic obstructive pulmonary disease readmissions. American Journal of Respiratory and Critical Care Medicine, 189(6), 634-9.  Review American Association of Managed Care Nurses to explore information related to finance and payment structuring. Additional Instructions: All submissions should have a title page and reference page. Utilize a minimum of two scholarly resources. Adhere to grammar, spelling and punctuation criteria. Adhere to APA compliance guidelines. Adhere to the chosen Submission Option for Delivery of Activity guidelines. Submission Options: Choose One: Instructions: Paper 4 to 6-page paper. Include title and reference pages. Microsoft PowerPoint Presentation 8 to 10 slides. Add title and reference slides. Follow Rules of 7. Other media (Prezi, etc.) presentation 8 to 10 slides with speaker notes. Add title and reference slides. Follow Rules of 7. Video Presentation 5 to 8-minute video presentation. Attach reference page or include in video. Professional appearance and background. Video submissions must include a script in Word format, submitted through Turnitin for an Originality Report. Table Table with appropriate columns and headers. Include title and reference pages. Graphs or other illustrations Graphs or illustrations with appropriate labels. Include title and reference pages. Poster Poster utilizing any applicable poster template. Include visual graphics/images/other formats for visual appeal. Include appropriate title and references on poster. Note: Title and reference pages/slides do not count towards the count requirements.  RUBRIC: Collaboration for Improving Outcomes - Continuum of Care  Description: The baccalaureate graduate nurse will apply concepts of quality and safety to  identify clinical questions and describe the process of changing current practice.  Course Competencies: 2) Develop a holistic case management plan for a specified disease or  population that incorporates the role of insurance, health care finance, and utilization of  community resources. 3) Examine the role of case management in end of life care including  ethical and legal issues. 4) Coordinate the care of individuals across the lifespan utilizing  principles and knowledge of interdisciplinary models of care delivery and case management. QSEN Competencies: 1) Patient-Centered Care 2) Teamwork and Collaboration 3) EvidenceBased Practice  BSN Essential II Area Gold Mastery Silver Proficient  Bronze Acceptable  Acceptable  Mastery not  Demonstrated Explain how the  concept  continuum of care  is used in case  management and  within your  organization Explains how the  concept  continuum of care  is used in case  management and  within your  organization States how the  continuum of care  is used in case  management and  within your organization Lists how the  concept  continuum of care  is used in case  management and  within your  organization Does not  address the  topic Explain new  services/programs  that your  organization is  currently  evaluating or  performing that  are assisting  patients to reach  their health goals  Explains new  services/programs  that your  organization is  currently  evaluating or  performing that  are assisting  patients to reach  their health goals  States new  services/programs  that your  organization is  currently  evaluating or  performing that  are assisting  patients to reach  their health goals  Lists new  services/programs  that your  organization is  currently  evaluating or  performing that  are assisting  patients to reach  their health goals Does not  address the  topic Explain how  these new  services/programs  can impact the  bottom line of the  organization. Explains how  new  services/programs  can impact the  bottom line of the  organization. States how new  services/programs  can impact the  bottom line of the  organization. Lists how new  services/programs  can impact the  bottom line of the  organization. Does not  address the  topic Choose a quality  indicator and  discuss how it can  influence quality  of care Chooses a quality  indicator and  explains how it  can influence  quality of care Chooses a quality  indicator and  states how it can  influence quality  of care Chooses a quality  indicator but  doesn’t discuss  how it can  influence care Does not  address the  topic Assesses the  practice of linking  hospital  reimbursement to  Assesses the  practice of  linking hospital  reimbursement to  Explains the  practice of  linking hospital  reimbursement to  Lists the practice  of linking  hospital  reimbursement to  Does not  address the  topicperformance  outcomes performance  outcomes performance  outcomes performance  outcomes  APA, Grammar, Spelling, and  Punctuation No errors in  APA, Spelling,  and Punctuation. One to three  errors in APA,  Spelling, and  Punctuation. Four to six errors  in APA, Spelling,  and Punctuation. Seven or more  errors in APA,  Spelling, and  Punctuation. References Provides two or  more references. Provides two  references. Provides one  references. Provides no  references