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Pathology notes

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INTERPRETATION OF PERIPHERAL BLOOD SMEARS Dorah Wang’alia Defination • When a peripheral blood sample is smeared on a slide and stained, it is known as a peripheral blood film often follows a complete blood count • It allows for examination of the physical characteristics of the red cells, white cells and platelets under the microscope. Additionally, it helps detect parasites or abnormal cells in the blood. Thus the peripheral blood film is an important indicator of haematological and other disease. Information provided on the peripheral blood films • The erythrocytes (red blood cells): a note will be made of their size, shape, any membrane changes, colour and stippling. Any inclusion bodies (eg, Howell-Jolly bodies or malarial parasites) will also be noted. Other abnormalities include red cell rouleaux, red cell nucleation and the presence of reticulocytes. • The leukocytes (white blood cells): the number and morphology of these cells are noted, as well as abnormalities such as toxic granulation or dysplastic changes. Presence of abnormal cells is important (eg, leukaemic blasts). • Platelets: number, size and shape are commented on. • Other abnormalities such as parasites, plasma cells and occasional circulating carcinoma cells may be found. • • Preferred Specimen(s) 2 slides Peripheral Blood Smear Instructions: 2 glass microscope slide-peripheral smears (preferred) 2 smears, unfixed, air-dried accompanied by CBC 9complete blood count0profile info ...
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