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FULL COURSE OF HEMOGLOBIN ( INTRODUCTION ) CHEMICAL STRUCTURE AND COMPOSTION OF HB

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HEMOGLOBIN Muhammad Adil Abid Mohammadadilabid1996@gmail.com ANCHORING QUESTIONS • What is Hemoglobin? • What is its role? • Where and how is it synthesized? • What is the structure of HB? CHEMICAL STRUCTURE INTRODUCTION • The main function of red blood cell: • Transfer of O2 from lungs to tissue • Transfer of CO2 from tissue to lungs • To accomplish this function red cells has hemoglobin (Hb) • Each red cell has 640 million molecules of Hb. INTRODUCTION • Hemoglobin (Hb), protein constituting 1/3 of the red blood cells. • Synthesis begins in polychromatic normoblast stage • 65% at erythroblast stage • 35% at reticulocyte stage • Two parts • Heme • Globin HEMOGLOBIN • Hemoglobin is a conjugated protein • constitutes 33% of the erythrocyte’s weight by volume. • Hemoglobin has a molecular weight of 68,000 making it a large protein. COMPOSITION of HB • Each hemoglobin molecule consists of 4 heme groups and 4 globin molecule. • Each Heme group contains a protoporphyrin ring plus an iron molecule. • Each Globin consists of 4 polypeptide chains (2 pairs). • Synthesis of protoporphyrin and globin is well coordinated. • If production of one decreases the production of the other also decreases. SYNTHESIS of HB • Heme & globin produced at two different sites in the cells. • Heme in mitochondria • Globin in polyribosomes • Well synchronized SYNTHESIS of HB HEME FORMATION • Heme formation takes place in the M ...
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