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Article review

Article review

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Running Head: ARTICLE REVIEW 1

Article review

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ARTICLE REVIEW 2

A bulky glycocalyx fosters metastasis formation by promoting G1 cell cycle progression

Introduction

Metastasis is the medical definition of cancerous cells that spreads from the original part

of the body to other parts of the body. The researchers of the above mentioned article sought to

study how glycocalyx speeds up metastasis by promoting G1 cell cycle progression. The article

is written based on research evidence on how a protein such as glycocalyx fosters metastasis

formation. Additionally they sought to understand how mucins promote malignancy in the body

organs. Cancer cells are transferred from the original point in the body to other pats through

blood streams and lymph systems. The lymph system is the one responsible for transfer of body

proteins such as mucins. The article is meant to study the effects of glycocalx in fostering

metastasis formation. According to the article, malignancy is attributed to altered formation of

glycans and glycoproteins that lead to formation of glycocalyx. Additionally, the paper shows a

construction of glycoprotein which showed that metastatic cancer regulates bulky glycoproteins.

Methods

The researchers used mice as test subjected in the research. They were tested in a lab to

determine the results of the study. The method used for the stud involved synthesis of

glcopolymers, acquisition of mfc- ions. Additionally glycopolymers were loaded onto a cell

surface. The researchers then observed the reactions of different glycoprotein cells. The mice

used were tested to determine the results of the study as per the article. A mice tail vein

metastasis model method was used. The mice used were kept under university of California

animal care. Mice were restrained and tail vein injections were performed with 100 ml at 106

cells per ml. Mice were not fed doxycycline—Dox (+) cells were treated for 24 hr before

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Running Head: ARTICLE REVIEW 1 Article review Name Institution Date ARTICLE REVIEW 2 A bulky glycocalyx fosters metastasis formation by promoting G1 cell cycle progression Introduction Metastasis is the medical definition of cancerous cells that spreads from the original part of the body to other parts of the body. The researchers of the above mentioned article sought to study how glycocalyx speeds up metastasis by promoting G1 cell cycle progression. The article is written based on research evidence on how a protein such as glycocalyx fosters metastasis formation. Additionally they sought to understand how mucins promote malignancy in the body organs. Cancer cells are transferred from the original point in the body to other pats through blood streams and lymph systems. The lymph system is the one responsible for transfer of body proteins such as mucins. The article is meant to study the effects of glycocalx in fostering metastasis formation. According to the article, malignancy is attributed to altered formation of glycans and glycoproteins that lead to formation of glycocalyx. Additionally, the paper shows a construction of glycoprotein which showed that metastatic cancer regulates bulky glycoproteins. Methods The researchers used mice as test subjected in the research. They were tested in a lab to determine the results of the study. The method used for the stud involved synthesis of glcopolymers, acquisition of mfc- ions. Additionally glycopolymers were loaded onto a ...
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