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Santa Monica College
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Running head: NEUTRAL MUTATION AND CRPTIC VARIATION.
Neutral Mutation and Cryptic Variation
By (Name)
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MUTATION AND VARIATIONS
Introduction
Tamiflu had been one of the best treatments for flu as it treated the flu symptoms, but it
also reduced the virus's replication, causing the flu in the body. However, with time, the drug
was rendered useless as the flu virus's genetic material had mutated and phenotypically cryptic in
the DNA sequence.
All flu viruses are made up of a protein coat on their surface called Neuraminidase.
During DNA replication of cell, an error can occur, causing a change in the nucleotide sequence
resulting in Mutation. Cryptic variation arises when some DNA is not expressed due to
incapacity to function in one strand of the gene. Therefore virus utilized these Mutations to gain
more resistance to the Tamiflu drug. Tamiflu functions because it gums up on the virus protein
neuraminidase, thus trapping it against its spread. Due to the random Mutation caused by
inefficient transcription and replication of cells, the virus mutated, breaking away from the
Tamiflu drug's gamming. A Neutral mutation develops when DNA genotype produces a similar
phenotype because the genetic code is redundant. The flu used the variations to mutate its
neuraminidase protein and spread efficiently in the body ("Chance and Evolution - Probability
Alone Should End the Debate", 2021)
Cryptic variation study is significant in providing potential solutions to human health.
The study looks into ways to combat diseases and conditions by providing toxic drugs to destroy
bacteria, fungi, and viruses that cause harmful effects on the body. For example, through the

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Running head: NEUTRAL MUTATION AND CRPTIC VARIATION. Neutral Mutation and Cryptic Variation By (Name) Course Professor Date 2 MUTATION AND VARIATIONS Introduction Tamiflu had been one of the best treatments for flu as it treated the flu symptoms, but it also reduced the virus's replication, causing the flu in the body. However, with time, the drug was rendered useless as the flu virus's genetic material had mutated and phenotypically cryptic in the DNA sequence. All flu viruses are made up of a protein coat on their surface called Neuraminidase. During DNA replication of cell, an error can occur, causing a change in the nucleotide sequence resulting in Mutation. Cryptic variation arises when some DNA is not expressed due to incapacity to function in one strand of the gene. Therefore virus utilized these Mutations to gain more resistance to the Tamiflu drug. Tamiflu functions because it gums up on the virus protein neuraminidase, thus trapping it against its spread. Due to the random Mutation caused by inefficient transcription and replication of cells, the virus mutated, breaking away from the Tamiflu drug's gamming. A Neutral mutation develops when DNA genotype produces a si ...
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